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[Abnormalities of hypotonic orthostatic regulation: cardiovascular effects of dihydroergotamine, etilefrine and their combination (author's transl)].
Dtsch Med Wochenschr. 1981 Aug 28; 106(35):1095-9.DM

Abstract

In a double-blind inter-individual study of 51 patients with abnormal hypotonic orthostatic regulation, the effect of dihydroergotamine (2 mg), etilefrine (20 mg) or their combination (2 mg and 20 mg, respectively) was studied. Blood pressure, heart rate, dicrotic ratio as well as number and severity of symptoms during standardised orthostasis were studied before and after a week on placebo and after one and two weeks of drug administration. Resting blood pressure after treatment with the two drugs combined rose from 111/73 to 120/77 mm Hg, after etilefrine from 114/74 to 122/79 mm Hg, remaining essentially unchanged after dihydroergotamine. Fall in dicrotic ratio, as a measure of change in mean blood pressure, was 10% during the first minute of standing with the combined drugs, 30-35% with each drug separately. Treatment with the combined drugs was also superior when considering systolic blood pressure, pressure amplitude and heart rate. Similarly, the drugs in combination caused the least number and lowest severity of symptoms: side-effects were less common with the combination than with each drug alone.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

6114845

Citation

Gemeinhardt, S, et al. "[Abnormalities of Hypotonic Orthostatic Regulation: Cardiovascular Effects of Dihydroergotamine, Etilefrine and Their Combination (author's Transl)]." Deutsche Medizinische Wochenschrift (1946), vol. 106, no. 35, 1981, pp. 1095-9.
Gemeinhardt S, Schardt F, Polzien P. [Abnormalities of hypotonic orthostatic regulation: cardiovascular effects of dihydroergotamine, etilefrine and their combination (author's transl)]. Dtsch Med Wochenschr. 1981;106(35):1095-9.
Gemeinhardt, S., Schardt, F., & Polzien, P. (1981). [Abnormalities of hypotonic orthostatic regulation: cardiovascular effects of dihydroergotamine, etilefrine and their combination (author's transl)]. Deutsche Medizinische Wochenschrift (1946), 106(35), 1095-9.
Gemeinhardt S, Schardt F, Polzien P. [Abnormalities of Hypotonic Orthostatic Regulation: Cardiovascular Effects of Dihydroergotamine, Etilefrine and Their Combination (author's Transl)]. Dtsch Med Wochenschr. 1981 Aug 28;106(35):1095-9. PubMed PMID: 6114845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Abnormalities of hypotonic orthostatic regulation: cardiovascular effects of dihydroergotamine, etilefrine and their combination (author's transl)]. AU - Gemeinhardt,S, AU - Schardt,F, AU - Polzien,P, PY - 1981/8/28/pubmed PY - 1981/8/28/medline PY - 1981/8/28/entrez SP - 1095 EP - 9 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 106 IS - 35 N2 - In a double-blind inter-individual study of 51 patients with abnormal hypotonic orthostatic regulation, the effect of dihydroergotamine (2 mg), etilefrine (20 mg) or their combination (2 mg and 20 mg, respectively) was studied. Blood pressure, heart rate, dicrotic ratio as well as number and severity of symptoms during standardised orthostasis were studied before and after a week on placebo and after one and two weeks of drug administration. Resting blood pressure after treatment with the two drugs combined rose from 111/73 to 120/77 mm Hg, after etilefrine from 114/74 to 122/79 mm Hg, remaining essentially unchanged after dihydroergotamine. Fall in dicrotic ratio, as a measure of change in mean blood pressure, was 10% during the first minute of standing with the combined drugs, 30-35% with each drug separately. Treatment with the combined drugs was also superior when considering systolic blood pressure, pressure amplitude and heart rate. Similarly, the drugs in combination caused the least number and lowest severity of symptoms: side-effects were less common with the combination than with each drug alone. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/6114845/[Abnormalities_of_hypotonic_orthostatic_regulation:_cardiovascular_effects_of_dihydroergotamine_etilefrine_and_their_combination__author's_transl_]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1070462 DB - PRIME DP - Unbound Medicine ER -