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Serum cotinine levels in pipe smokers: evidence against nicotine as cause of coronary heart disease.
Lancet. 1981 Oct 10; 2(8250):775-7.Lct

Abstract

Serum levels of cotinine (a principal metabolite of nicotine) were studied in men who did not smoke (28), and in men who smoked cigarettes only (150), cigars only (70), and pipes only (56). The mean cotinine level for pipe smokers was 389 ng/ml, significantly higher than the mean level for cigarette and cigar smokers (306 and 121 ng/ml, respectively); no cotinine was detected in the serum from any of the non-smokers. Large prospective studies have shown that pipe smokers have no material excess risk of coronary heart disease but cigarette smokers do, so that our observations indicate that nicotine is unlikely to be the major cause of the excess coronary heart disease mortality in cigarette smokers.

Authors

Wald NJ
No affiliation info available
Idle M
No affiliation info available
Boreham J
No affiliation info available
Bailey A
No affiliation info available

MeSH

AdultCarboxyhemoglobinCoronary DiseaseCotinineHumansMaleMiddle AgedMouth MucosaNicotineProspective StudiesPyrrolidinonesRiskSmoking

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6116905

Citation

Wald, N J., et al. "Serum Cotinine Levels in Pipe Smokers: Evidence Against Nicotine as Cause of Coronary Heart Disease." Lancet (London, England), vol. 2, no. 8250, 1981, pp. 775-7.
Wald NJ, Idle M, Boreham J, et al. Serum cotinine levels in pipe smokers: evidence against nicotine as cause of coronary heart disease. Lancet. 1981;2(8250):775-7.
Wald, N. J., Idle, M., Boreham, J., & Bailey, A. (1981). Serum cotinine levels in pipe smokers: evidence against nicotine as cause of coronary heart disease. Lancet (London, England), 2(8250), 775-7.
Wald NJ, et al. Serum Cotinine Levels in Pipe Smokers: Evidence Against Nicotine as Cause of Coronary Heart Disease. Lancet. 1981 Oct 10;2(8250):775-7. PubMed PMID: 6116905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cotinine levels in pipe smokers: evidence against nicotine as cause of coronary heart disease. AU - Wald,N J, AU - Idle,M, AU - Boreham,J, AU - Bailey,A, PY - 1981/10/10/pubmed PY - 1981/10/10/medline PY - 1981/10/10/entrez SP - 775 EP - 7 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 8250 N2 - Serum levels of cotinine (a principal metabolite of nicotine) were studied in men who did not smoke (28), and in men who smoked cigarettes only (150), cigars only (70), and pipes only (56). The mean cotinine level for pipe smokers was 389 ng/ml, significantly higher than the mean level for cigarette and cigar smokers (306 and 121 ng/ml, respectively); no cotinine was detected in the serum from any of the non-smokers. Large prospective studies have shown that pipe smokers have no material excess risk of coronary heart disease but cigarette smokers do, so that our observations indicate that nicotine is unlikely to be the major cause of the excess coronary heart disease mortality in cigarette smokers. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/6116905/Serum_cotinine_levels_in_pipe_smokers:_evidence_against_nicotine_as_cause_of_coronary_heart_disease_ DB - PRIME DP - Unbound Medicine ER -