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[Effect of L-ascorbic and D-isoascorbic acids on induced formation of tyrosine aminotransferase in rat liver].
Vopr Med Khim. 1981; 27(4):500-3.VM

Abstract

Administration of ascorbic acid at moderate doses/0.05-0.1 g per kg of body mass/was shown to induce tyrosine transaminase in liver tissue of intact rats. The enzyme induction depended on the state of adrenal glands and was inhibited by actinomycin D. As distinct from the native form of L-ascorbic acid moderate doses of D-isoascorbic acid did not induce the enzyme in rat liver tissue; these data suggest the relative biological inactivity of D-isoascorbic acid.

Authors

Levchuk AA
No affiliation info available
Bukin IuV
No affiliation info available
Smirnova KD
No affiliation info available
Raushenbakh MO
No affiliation info available
Rubtsov IA
No affiliation info available

MeSH

Adrenal GlandsAdrenalectomyAnimalsAscorbic AcidDactinomycinEnzyme InductionHydrocortisoneLiverMaleRatsRats, Inbred StrainsTyrosine Transaminase

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

6117152

Citation

Levchuk, A A., et al. "[Effect of L-ascorbic and D-isoascorbic Acids On Induced Formation of Tyrosine Aminotransferase in Rat Liver]." Voprosy Meditsinskoi Khimii, vol. 27, no. 4, 1981, pp. 500-3.
Levchuk AA, Bukin IuV, Smirnova KD, et al. [Effect of L-ascorbic and D-isoascorbic acids on induced formation of tyrosine aminotransferase in rat liver]. Vopr Med Khim. 1981;27(4):500-3.
Levchuk, A. A., Bukin, I. u. V., Smirnova, K. D., Raushenbakh, M. O., & Rubtsov, I. A. (1981). [Effect of L-ascorbic and D-isoascorbic acids on induced formation of tyrosine aminotransferase in rat liver]. Voprosy Meditsinskoi Khimii, 27(4), 500-3.
Levchuk AA, et al. [Effect of L-ascorbic and D-isoascorbic Acids On Induced Formation of Tyrosine Aminotransferase in Rat Liver]. Vopr Med Khim. 1981;27(4):500-3. PubMed PMID: 6117152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of L-ascorbic and D-isoascorbic acids on induced formation of tyrosine aminotransferase in rat liver]. AU - Levchuk,A A, AU - Bukin,Iu V, AU - Smirnova,K D, AU - Raushenbakh,M O, AU - Rubtsov,I A, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 500 EP - 3 JF - Voprosy meditsinskoi khimii JO - Vopr Med Khim VL - 27 IS - 4 N2 - Administration of ascorbic acid at moderate doses/0.05-0.1 g per kg of body mass/was shown to induce tyrosine transaminase in liver tissue of intact rats. The enzyme induction depended on the state of adrenal glands and was inhibited by actinomycin D. As distinct from the native form of L-ascorbic acid moderate doses of D-isoascorbic acid did not induce the enzyme in rat liver tissue; these data suggest the relative biological inactivity of D-isoascorbic acid. SN - 0042-8809 UR - https://www.unboundmedicine.com/medline/citation/6117152/[Effect_of_L_ascorbic_and_D_isoascorbic_acids_on_induced_formation_of_tyrosine_aminotransferase_in_rat_liver]_ L2 - https://medlineplus.gov/vitaminc.html DB - PRIME DP - Unbound Medicine ER -