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Absence of islet alpha cell function in pancreatectomized patients.
Diabetologia. 1982 Jan; 22(1):25-32.D

Abstract

Plasma immunoreactive glucagon, C-peptide and substrates (glucose, lactate, and alanine) were measured in 21 pancreatectomized patients and 28 patients with chronic calcifying pancreatitis during arginine infusion. Results were compared with those obtained in control and in insulin-dependent diabetic subjects, and in pancreatectomized subjects receiving a combined infusion of glucagon and arginine or somatostatin and arginine. Plasma immunoreactive glucagon in the pancreatectomized patients was 230 +/- 26 pg/ml (control subjects 100 +/- 13 pg/ml, p less than 0.001), but was unchanged following arginine or somatostatin. Following ethanol extraction of plasma it became undetectable. Similar results were obtained in patients with chronic pancreatitis. In contrast to the insulin-dependent diabetic subjects, no changes in blood glucose, lactate, and alanine concentrations were found during arginine infusion in the pancreatectomized or pancreatitis patients. Addition of glucagon restored the metabolic response to arginine in the pancreatectomized patients. Our results confirm previous smaller studies that in pancreatectomized patients, A cell function is absent or insignificant.

Authors

Tiengo A
No affiliation info available
Bessioud M
No affiliation info available
Valverde I
No affiliation info available
Tabbi-Anneni A
No affiliation info available
Delprato S
No affiliation info available
Alexandre J
No affiliation info available
Assan R
No affiliation info available

MeSH

AdultArginineC-PeptideDiabetes MellitusFemaleGlucagonHumansIslets of LangerhansMalePancreatectomyPancreatic Function TestsPancreatitisSomatostatin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6120875

Clinical Trial Links

Assay for the Pancreatic Polypeptide: an Help for Clinical Practice Guidelines in Classification of the Diabetes

Citation

Tiengo, A, et al. "Absence of Islet Alpha Cell Function in Pancreatectomized Patients." Diabetologia, vol. 22, no. 1, 1982, pp. 25-32.
Tiengo A, Bessioud M, Valverde I, et al. Absence of islet alpha cell function in pancreatectomized patients. Diabetologia. 1982;22(1):25-32.
Tiengo, A., Bessioud, M., Valverde, I., Tabbi-Anneni, A., Delprato, S., Alexandre, J., & Assan, R. (1982). Absence of islet alpha cell function in pancreatectomized patients. Diabetologia, 22(1), 25-32.
Tiengo A, et al. Absence of Islet Alpha Cell Function in Pancreatectomized Patients. Diabetologia. 1982;22(1):25-32. PubMed PMID: 6120875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Absence of islet alpha cell function in pancreatectomized patients. AU - Tiengo,A, AU - Bessioud,M, AU - Valverde,I, AU - Tabbi-Anneni,A, AU - Delprato,S, AU - Alexandre,J, AU - Assan,R, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 25 EP - 32 JF - Diabetologia JO - Diabetologia VL - 22 IS - 1 N2 - Plasma immunoreactive glucagon, C-peptide and substrates (glucose, lactate, and alanine) were measured in 21 pancreatectomized patients and 28 patients with chronic calcifying pancreatitis during arginine infusion. Results were compared with those obtained in control and in insulin-dependent diabetic subjects, and in pancreatectomized subjects receiving a combined infusion of glucagon and arginine or somatostatin and arginine. Plasma immunoreactive glucagon in the pancreatectomized patients was 230 +/- 26 pg/ml (control subjects 100 +/- 13 pg/ml, p less than 0.001), but was unchanged following arginine or somatostatin. Following ethanol extraction of plasma it became undetectable. Similar results were obtained in patients with chronic pancreatitis. In contrast to the insulin-dependent diabetic subjects, no changes in blood glucose, lactate, and alanine concentrations were found during arginine infusion in the pancreatectomized or pancreatitis patients. Addition of glucagon restored the metabolic response to arginine in the pancreatectomized patients. Our results confirm previous smaller studies that in pancreatectomized patients, A cell function is absent or insignificant. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/6120875/Absence_of_islet_alpha_cell_function_in_pancreatectomized_patients_ L2 - https://ClinicalTrials.gov/search/term=6120875 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -