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Evidence for histamine and 5-hydroxytryptamine like effects of MK-212 on guinea pig ileum, taenia coli and rat fundus strip.
Indian J Physiol Pharmacol. 1981 Oct-Dec; 25(4):379-84.IJ

Abstract

MK-212 (1 x 10(-7)M -- 1 x 10(-5)M) produced dose-dependent contractions of guinea pig ileum, taenia coil and rat fundus strip. The responses to MK-212 in all three preparations were blocked competitively by cyproheptadine (1 x 10(-8)M) a 5-HT receptor antagonist. Mepyramine (1 x 10(-8)M)-H1 receptor antagonist also inhibited competitively the responses of guinea pig ileum and taenia coli to MK-212. However, it failed to block significantly the responses of rat fundus strip to MK-212. Metiamide (1 x 10(-6)M), propranolol (1 x 10(-6)M) or atropine (1 x 10(-6)M) did not produce any significant effects on MK-212 induced contractile responses of guinea pig ileum, taenia coli and rat fundus strip. Our findings suggest that MK-212 produces both 5-HT as well as histamine like effects on the guinea-pig ileum, taenia coli and rat fundus strip.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6122646

Citation

Patel, U P., and S C. Verma. "Evidence for Histamine and 5-hydroxytryptamine Like Effects of MK-212 On Guinea Pig Ileum, Taenia Coli and Rat Fundus Strip." Indian Journal of Physiology and Pharmacology, vol. 25, no. 4, 1981, pp. 379-84.
Patel UP, Verma SC. Evidence for histamine and 5-hydroxytryptamine like effects of MK-212 on guinea pig ileum, taenia coli and rat fundus strip. Indian J Physiol Pharmacol. 1981;25(4):379-84.
Patel, U. P., & Verma, S. C. (1981). Evidence for histamine and 5-hydroxytryptamine like effects of MK-212 on guinea pig ileum, taenia coli and rat fundus strip. Indian Journal of Physiology and Pharmacology, 25(4), 379-84.
Patel UP, Verma SC. Evidence for Histamine and 5-hydroxytryptamine Like Effects of MK-212 On Guinea Pig Ileum, Taenia Coli and Rat Fundus Strip. Indian J Physiol Pharmacol. 1981 Oct-Dec;25(4):379-84. PubMed PMID: 6122646.
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TY - JOUR T1 - Evidence for histamine and 5-hydroxytryptamine like effects of MK-212 on guinea pig ileum, taenia coli and rat fundus strip. AU - Patel,U P, AU - Verma,S C, PY - 1981/10/1/pubmed PY - 1981/10/1/medline PY - 1981/10/1/entrez SP - 379 EP - 84 JF - Indian journal of physiology and pharmacology JO - Indian J. Physiol. Pharmacol. VL - 25 IS - 4 N2 - MK-212 (1 x 10(-7)M -- 1 x 10(-5)M) produced dose-dependent contractions of guinea pig ileum, taenia coil and rat fundus strip. The responses to MK-212 in all three preparations were blocked competitively by cyproheptadine (1 x 10(-8)M) a 5-HT receptor antagonist. Mepyramine (1 x 10(-8)M)-H1 receptor antagonist also inhibited competitively the responses of guinea pig ileum and taenia coli to MK-212. However, it failed to block significantly the responses of rat fundus strip to MK-212. Metiamide (1 x 10(-6)M), propranolol (1 x 10(-6)M) or atropine (1 x 10(-6)M) did not produce any significant effects on MK-212 induced contractile responses of guinea pig ileum, taenia coli and rat fundus strip. Our findings suggest that MK-212 produces both 5-HT as well as histamine like effects on the guinea-pig ileum, taenia coli and rat fundus strip. SN - 0019-5499 UR - https://www.unboundmedicine.com/medline/citation/6122646/Evidence_for_histamine_and_5_hydroxytryptamine_like_effects_of_MK_212_on_guinea_pig_ileum_taenia_coli_and_rat_fundus_strip_ L2 - https://www.lens.org/lens/search?q=citation_id:6122646 DB - PRIME DP - Unbound Medicine ER -