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Beta-adrenoceptor blockade and psychic stress in man. A comparison of the acute effects of labetalol, metoprolol, pindolol and propranolol on plasma levels of adrenaline and noradrenaline.
Br J Clin Pharmacol. 1982; 13(Suppl 2):391S-395S.BJ

Abstract

1 A random double-blind study was performed in healthy volunteers. The immediate effects of three different beta-adrenoceptor blocking agents, metoprolol, pindolol and propranolol, on the plasma concentrations of adrenaline and noradrenaline were compared in a situation of pleasant psychic stimulation during a television-game of tennis. The immediate effects of labetalol in a group of patients with arterial hypertension were studied in a similar experimental situation. 2 During psychic stress the plasma concentration of noradrenaline rose significantly by 85% after placebo, by 95% after labetalol, by 63% after metoprolol and by 55% after propranolol. After pindolol the noradrenaline concentration remained unchanged. 3 During psychic stress the plasma concentration of adrenaline rose significantly by 135% after labetalol, by 110% after metoprolol and by 83% after propranolol. After pindolol and placebo the adrenaline concentration remained unchanged. 4 The present results are taken to indicate that the intrinsic sympathomimetic activity possessed by pindolol prevents the rise in plasma noradrenaline normally seen during psychic stress. It is suggested that beta-adrenoceptor blockers with strong intrinsic sympathomimetic effect reduce the release of catecholamines during psychic stress.

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Authors

Trap-Jensen J
No affiliation info available
Carlsen JE
No affiliation info available
Hartling OJ
No affiliation info available
Svendsen TL
No affiliation info available
Tangø M
No affiliation info available
Christensen NJ
No affiliation info available

MeSH

Adrenergic beta-AntagonistsAdultCatecholaminesEpinephrineHumansLabetalolMaleMetoprololNorepinephrinePindololPropranololStress, Psychological

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6125191

Citation

Trap-Jensen, J, et al. "Beta-adrenoceptor Blockade and Psychic Stress in Man. a Comparison of the Acute Effects of Labetalol, Metoprolol, Pindolol and Propranolol On Plasma Levels of Adrenaline and Noradrenaline." British Journal of Clinical Pharmacology, vol. 13, no. Suppl 2, 1982, 391S-395S.
Trap-Jensen J, Carlsen JE, Hartling OJ, et al. Beta-adrenoceptor blockade and psychic stress in man. A comparison of the acute effects of labetalol, metoprolol, pindolol and propranolol on plasma levels of adrenaline and noradrenaline. Br J Clin Pharmacol. 1982;13(Suppl 2):391S-395S.
Trap-Jensen, J., Carlsen, J. E., Hartling, O. J., Svendsen, T. L., Tangø, M., & Christensen, N. J. (1982). Beta-adrenoceptor blockade and psychic stress in man. A comparison of the acute effects of labetalol, metoprolol, pindolol and propranolol on plasma levels of adrenaline and noradrenaline. British Journal of Clinical Pharmacology, 13(Suppl 2), 391S-395S.
Trap-Jensen J, et al. Beta-adrenoceptor Blockade and Psychic Stress in Man. a Comparison of the Acute Effects of Labetalol, Metoprolol, Pindolol and Propranolol On Plasma Levels of Adrenaline and Noradrenaline. Br J Clin Pharmacol. 1982;13(Suppl 2):391S-395S. PubMed PMID: 6125191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beta-adrenoceptor blockade and psychic stress in man. A comparison of the acute effects of labetalol, metoprolol, pindolol and propranolol on plasma levels of adrenaline and noradrenaline. AU - Trap-Jensen,J, AU - Carlsen,J E, AU - Hartling,O J, AU - Svendsen,T L, AU - Tangø,M, AU - Christensen,N J, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 391S EP - 395S JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 13 IS - Suppl 2 N2 - 1 A random double-blind study was performed in healthy volunteers. The immediate effects of three different beta-adrenoceptor blocking agents, metoprolol, pindolol and propranolol, on the plasma concentrations of adrenaline and noradrenaline were compared in a situation of pleasant psychic stimulation during a television-game of tennis. The immediate effects of labetalol in a group of patients with arterial hypertension were studied in a similar experimental situation. 2 During psychic stress the plasma concentration of noradrenaline rose significantly by 85% after placebo, by 95% after labetalol, by 63% after metoprolol and by 55% after propranolol. After pindolol the noradrenaline concentration remained unchanged. 3 During psychic stress the plasma concentration of adrenaline rose significantly by 135% after labetalol, by 110% after metoprolol and by 83% after propranolol. After pindolol and placebo the adrenaline concentration remained unchanged. 4 The present results are taken to indicate that the intrinsic sympathomimetic activity possessed by pindolol prevents the rise in plasma noradrenaline normally seen during psychic stress. It is suggested that beta-adrenoceptor blockers with strong intrinsic sympathomimetic effect reduce the release of catecholamines during psychic stress. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/6125191/Beta_adrenoceptor_blockade_and_psychic_stress_in_man__A_comparison_of_the_acute_effects_of_labetalol_metoprolol_pindolol_and_propranolol_on_plasma_levels_of_adrenaline_and_noradrenaline_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0306-5251&date=1982&volume=13&issue=Suppl 2&spage=391S DB - PRIME DP - Unbound Medicine ER -