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Discriminative stimulus properties of MDA analogs.
Biol Psychiatry. 1982 Jul; 17(7):807-14.BP

Abstract

Rats trained to discriminate (+/-) 2,5-dimethoxy-4-methylphenylisopropylamine (DOM) (1.0 mg/kg) from saline, using a standard two-lever operant task, were challenged with various doses of 3,4-methylenedioxyphenylisopropylamine (MDA) and several related agents. The (+/-)-DOM stimulus generalized to (+/-)-MDA, suggesting that both agents apparently produce similar stimulus cues. Related agents, known to produce effects in man similar to those produced by (+/-)-MDA, also resulted in generalization when administered to the DOM-trained animals, e.g., R(-)-MDA and a methoxylated derivative of (+/-)-MDA, (+/-)-2-OMe-4,5-MDA. DOM stimulus generalization was not observed for S(+)-MDA, the N-monomethyl and alpha-demethyl derivatives of MDA, nor for a metabolite of MDA (i.e., 3-methoxy-4-hydroxyphenylisopropylamine). The results suggest that R(-)- and (+/-)-MDA, as well as (+/-)-2-OMe-4,5-MDA, but not the other derivatives of MDA, are capable of producing behavioral (stimulus) effects common to those produced by the training dose of (+/-)-DOM.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6126227

Citation

Glennon, R A., et al. "Discriminative Stimulus Properties of MDA Analogs." Biological Psychiatry, vol. 17, no. 7, 1982, pp. 807-14.
Glennon RA, Young R, Rosecrans JA, et al. Discriminative stimulus properties of MDA analogs. Biol Psychiatry. 1982;17(7):807-14.
Glennon, R. A., Young, R., Rosecrans, J. A., & Anderson, G. M. (1982). Discriminative stimulus properties of MDA analogs. Biological Psychiatry, 17(7), 807-14.
Glennon RA, et al. Discriminative Stimulus Properties of MDA Analogs. Biol Psychiatry. 1982;17(7):807-14. PubMed PMID: 6126227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative stimulus properties of MDA analogs. AU - Glennon,R A, AU - Young,R, AU - Rosecrans,J A, AU - Anderson,G M, PY - 1982/7/1/pubmed PY - 1982/7/1/medline PY - 1982/7/1/entrez SP - 807 EP - 14 JF - Biological psychiatry JO - Biol Psychiatry VL - 17 IS - 7 N2 - Rats trained to discriminate (+/-) 2,5-dimethoxy-4-methylphenylisopropylamine (DOM) (1.0 mg/kg) from saline, using a standard two-lever operant task, were challenged with various doses of 3,4-methylenedioxyphenylisopropylamine (MDA) and several related agents. The (+/-)-DOM stimulus generalized to (+/-)-MDA, suggesting that both agents apparently produce similar stimulus cues. Related agents, known to produce effects in man similar to those produced by (+/-)-MDA, also resulted in generalization when administered to the DOM-trained animals, e.g., R(-)-MDA and a methoxylated derivative of (+/-)-MDA, (+/-)-2-OMe-4,5-MDA. DOM stimulus generalization was not observed for S(+)-MDA, the N-monomethyl and alpha-demethyl derivatives of MDA, nor for a metabolite of MDA (i.e., 3-methoxy-4-hydroxyphenylisopropylamine). The results suggest that R(-)- and (+/-)-MDA, as well as (+/-)-2-OMe-4,5-MDA, but not the other derivatives of MDA, are capable of producing behavioral (stimulus) effects common to those produced by the training dose of (+/-)-DOM. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/6126227/Discriminative_stimulus_properties_of_MDA_analogs_ DB - PRIME DP - Unbound Medicine ER -