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Fetal and maternal plasma levels of immunoreactive somatostatin at delivery: evidence for its increase in the umbilical artery and its arterio-venous gradient in the feto-placental circulation.
J Clin Endocrinol Metab. 1983 Mar; 56(3):567-71.JC

Abstract

The concentrations of immunoreactive somatostatin (IR-SRIF) in plasma samples taken from the umbilical artery (UA), umbilical vein (UV), and maternal antecubital vein (MV) were measured in 23 cases of normal delivery at term. High concentrations of IR-SRIF were detected in the plasma from the UA (mean +/- SD, 73.2 +/- 40.6 pg/ml), the value being about 2.5 times that in the UV (29.5 +/- 17.5 pg/ml; P less than 0.001). An arterio-venous gradient was observed in all 23 subjects. The plasma level of IR-SRIF in the MV (10.9 +/- 4.6 pg/ml) was significantly lower than those in the UA (P less than 0.001) and UV (P less than 0.001) and was almost the same as that in nonpregnant women (12.7 +/- 5.4 pg/ml). Chromatographic analysis of an extract of plasma from the UA gave only one peak of immunoreactive material, which was eluted in the same position as synthetic SRIF-14. A similar result was obtained in nonpregnant women. No correlation was found between the plasma level of IR-SRIF and that of GH, insulin, glucagon, or gastrin in the UA. The present findings suggest that the high concentration of IR-SRIF in the feto-placental circulation originates from the fetus and reflects a particular role of this peptide in the process of functional maturation of the neuroendocrine system in early human life.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6130103

Citation

Saito, H, et al. "Fetal and Maternal Plasma Levels of Immunoreactive Somatostatin at Delivery: Evidence for Its Increase in the Umbilical Artery and Its Arterio-venous Gradient in the Feto-placental Circulation." The Journal of Clinical Endocrinology and Metabolism, vol. 56, no. 3, 1983, pp. 567-71.
Saito H, Saito S, Sano T, et al. Fetal and maternal plasma levels of immunoreactive somatostatin at delivery: evidence for its increase in the umbilical artery and its arterio-venous gradient in the feto-placental circulation. J Clin Endocrinol Metab. 1983;56(3):567-71.
Saito, H., Saito, S., Sano, T., Hosoi, E., & Saito, H. (1983). Fetal and maternal plasma levels of immunoreactive somatostatin at delivery: evidence for its increase in the umbilical artery and its arterio-venous gradient in the feto-placental circulation. The Journal of Clinical Endocrinology and Metabolism, 56(3), 567-71.
Saito H, et al. Fetal and Maternal Plasma Levels of Immunoreactive Somatostatin at Delivery: Evidence for Its Increase in the Umbilical Artery and Its Arterio-venous Gradient in the Feto-placental Circulation. J Clin Endocrinol Metab. 1983;56(3):567-71. PubMed PMID: 6130103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fetal and maternal plasma levels of immunoreactive somatostatin at delivery: evidence for its increase in the umbilical artery and its arterio-venous gradient in the feto-placental circulation. AU - Saito,H, AU - Saito,S, AU - Sano,T, AU - Hosoi,E, AU - Saito,H, PY - 1983/3/1/pubmed PY - 1983/3/1/medline PY - 1983/3/1/entrez SP - 567 EP - 71 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 56 IS - 3 N2 - The concentrations of immunoreactive somatostatin (IR-SRIF) in plasma samples taken from the umbilical artery (UA), umbilical vein (UV), and maternal antecubital vein (MV) were measured in 23 cases of normal delivery at term. High concentrations of IR-SRIF were detected in the plasma from the UA (mean +/- SD, 73.2 +/- 40.6 pg/ml), the value being about 2.5 times that in the UV (29.5 +/- 17.5 pg/ml; P less than 0.001). An arterio-venous gradient was observed in all 23 subjects. The plasma level of IR-SRIF in the MV (10.9 +/- 4.6 pg/ml) was significantly lower than those in the UA (P less than 0.001) and UV (P less than 0.001) and was almost the same as that in nonpregnant women (12.7 +/- 5.4 pg/ml). Chromatographic analysis of an extract of plasma from the UA gave only one peak of immunoreactive material, which was eluted in the same position as synthetic SRIF-14. A similar result was obtained in nonpregnant women. No correlation was found between the plasma level of IR-SRIF and that of GH, insulin, glucagon, or gastrin in the UA. The present findings suggest that the high concentration of IR-SRIF in the feto-placental circulation originates from the fetus and reflects a particular role of this peptide in the process of functional maturation of the neuroendocrine system in early human life. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/6130103/Fetal_and_maternal_plasma_levels_of_immunoreactive_somatostatin_at_delivery:_evidence_for_its_increase_in_the_umbilical_artery_and_its_arterio_venous_gradient_in_the_feto_placental_circulation_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-56-3-567 DB - PRIME DP - Unbound Medicine ER -