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IgA antigliadin antibodies: a marker of mucosal damage in childhood coeliac disease.
Lancet. 1983 Feb 12; 1(8320):320-2.Lct

Abstract

Antigliadin antibodies in serum samples of 31 children with coeliac disease were measured by an enzyme-linked immunosorbent technique. In young patients (less than 2 years) tested before gluten withdrawal IgA antigliadin antibody levels were invariably above the levels of 36 controls. The titres fell rapidly when gluten was eliminated from the diet and rose on its reintroduction. The titres were not always greater than the control level in older untreated patients. IgA antigliadin antibodies seem to be a good marker of the immune reaction in the jejunum triggered by gluten. In 2 IgA-deficient patients gluten challenge caused an increase in IgM antigliadin antibodies, and at the same time the number of IgM-containing cells increased in the jejunal mucosa. Rising IgG antigliadin antibody levels after gluten elimination were seen in 6 patients, 5 of whom had very low complement C3 levels before gluten elimination.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6130332

Citation

Savilahti, E, et al. "IgA Antigliadin Antibodies: a Marker of Mucosal Damage in Childhood Coeliac Disease." Lancet (London, England), vol. 1, no. 8320, 1983, pp. 320-2.
Savilahti E, Viander M, Perkkiö M, et al. IgA antigliadin antibodies: a marker of mucosal damage in childhood coeliac disease. Lancet. 1983;1(8320):320-2.
Savilahti, E., Viander, M., Perkkiö, M., Vainio, E., Kalimo, K., & Reunala, T. (1983). IgA antigliadin antibodies: a marker of mucosal damage in childhood coeliac disease. Lancet (London, England), 1(8320), 320-2.
Savilahti E, et al. IgA Antigliadin Antibodies: a Marker of Mucosal Damage in Childhood Coeliac Disease. Lancet. 1983 Feb 12;1(8320):320-2. PubMed PMID: 6130332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgA antigliadin antibodies: a marker of mucosal damage in childhood coeliac disease. AU - Savilahti,E, AU - Viander,M, AU - Perkkiö,M, AU - Vainio,E, AU - Kalimo,K, AU - Reunala,T, PY - 1983/2/12/pubmed PY - 1983/2/12/medline PY - 1983/2/12/entrez SP - 320 EP - 2 JF - Lancet (London, England) JO - Lancet VL - 1 IS - 8320 N2 - Antigliadin antibodies in serum samples of 31 children with coeliac disease were measured by an enzyme-linked immunosorbent technique. In young patients (less than 2 years) tested before gluten withdrawal IgA antigliadin antibody levels were invariably above the levels of 36 controls. The titres fell rapidly when gluten was eliminated from the diet and rose on its reintroduction. The titres were not always greater than the control level in older untreated patients. IgA antigliadin antibodies seem to be a good marker of the immune reaction in the jejunum triggered by gluten. In 2 IgA-deficient patients gluten challenge caused an increase in IgM antigliadin antibodies, and at the same time the number of IgM-containing cells increased in the jejunal mucosa. Rising IgG antigliadin antibody levels after gluten elimination were seen in 6 patients, 5 of whom had very low complement C3 levels before gluten elimination. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/6130332/IgA_antigliadin_antibodies:_a_marker_of_mucosal_damage_in_childhood_coeliac_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(83)91627-6 DB - PRIME DP - Unbound Medicine ER -