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Somatostatin-28 and somatostatin-14 suppression of arginine-, insulin-, and TRH-stimulated GH and PRL secretion in man.
Clin Endocrinol (Oxf). 1983 Mar; 18(3):277-85.CE

Abstract

GH and PRL responses to arginine infusion and to the combined pituitary stimulation test (0.1 u/kg of insulin, 200 micrograms of TRH, 100 micrograms of LHRH) were compared in five normal men during infusions of somatostatin-14 (SS-14) and somatostatin-28 (SS-28), and during control infusions of vehicle alone. SS-14 and SS-28 were infused at a rate of 1.8 nmol/kg over 210 min. Arginine (0.5 g/kg) was infused from 30 to 60 min and the combined pituitary stimulation test commenced at 120 min. Arginine (0.5 g/kg) infused from 30 to 60 min induced an increase in GH secretion in all subjects and this increase was completely abolished in these same subjects when infused with SS-14 and SS-28. Arginine-induced hyperglycaemia was significantly greater during infusion of SS-14 and further enhanced by infusion of SS-28. A small increase in PRL secretion occurred after arginine infusion and this was not inhibited by SS-14 or SS-28. Insulin and TRH administration induced marked increases in both GH and PRL secretion. The mean GH increase was significantly inhibited by SS-14 and SS-28 up to 165 min but not thereafter. The PRL increase was significantly inhibited by SS-28 but not by SS-14 and this greater efficacy was also indicated by administering different doses of SS-28 to one subject. Taken together with the demonstration that SS-28 is released from the median eminence, these findings indicate that SS-28 has a hormonal role in the regulation of GH and PRL secretion.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6134596

Citation

Millar, R P., et al. "Somatostatin-28 and Somatostatin-14 Suppression of Arginine-, Insulin-, and TRH-stimulated GH and PRL Secretion in Man." Clinical Endocrinology, vol. 18, no. 3, 1983, pp. 277-85.
Millar RP, Klaff LJ, Barron JL, et al. Somatostatin-28 and somatostatin-14 suppression of arginine-, insulin-, and TRH-stimulated GH and PRL secretion in man. Clin Endocrinol (Oxf). 1983;18(3):277-85.
Millar, R. P., Klaff, L. J., Barron, J. L., Levitt, N. S., & Ling, N. (1983). Somatostatin-28 and somatostatin-14 suppression of arginine-, insulin-, and TRH-stimulated GH and PRL secretion in man. Clinical Endocrinology, 18(3), 277-85.
Millar RP, et al. Somatostatin-28 and Somatostatin-14 Suppression of Arginine-, Insulin-, and TRH-stimulated GH and PRL Secretion in Man. Clin Endocrinol (Oxf). 1983;18(3):277-85. PubMed PMID: 6134596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatostatin-28 and somatostatin-14 suppression of arginine-, insulin-, and TRH-stimulated GH and PRL secretion in man. AU - Millar,R P, AU - Klaff,L J, AU - Barron,J L, AU - Levitt,N S, AU - Ling,N, PY - 1983/3/1/pubmed PY - 1983/3/1/medline PY - 1983/3/1/entrez SP - 277 EP - 85 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 18 IS - 3 N2 - GH and PRL responses to arginine infusion and to the combined pituitary stimulation test (0.1 u/kg of insulin, 200 micrograms of TRH, 100 micrograms of LHRH) were compared in five normal men during infusions of somatostatin-14 (SS-14) and somatostatin-28 (SS-28), and during control infusions of vehicle alone. SS-14 and SS-28 were infused at a rate of 1.8 nmol/kg over 210 min. Arginine (0.5 g/kg) was infused from 30 to 60 min and the combined pituitary stimulation test commenced at 120 min. Arginine (0.5 g/kg) infused from 30 to 60 min induced an increase in GH secretion in all subjects and this increase was completely abolished in these same subjects when infused with SS-14 and SS-28. Arginine-induced hyperglycaemia was significantly greater during infusion of SS-14 and further enhanced by infusion of SS-28. A small increase in PRL secretion occurred after arginine infusion and this was not inhibited by SS-14 or SS-28. Insulin and TRH administration induced marked increases in both GH and PRL secretion. The mean GH increase was significantly inhibited by SS-14 and SS-28 up to 165 min but not thereafter. The PRL increase was significantly inhibited by SS-28 but not by SS-14 and this greater efficacy was also indicated by administering different doses of SS-28 to one subject. Taken together with the demonstration that SS-28 is released from the median eminence, these findings indicate that SS-28 has a hormonal role in the regulation of GH and PRL secretion. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/6134596/Somatostatin_28_and_somatostatin_14_suppression_of_arginine__insulin__and_TRH_stimulated_GH_and_PRL_secretion_in_man_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1983&volume=18&issue=3&spage=277 DB - PRIME DP - Unbound Medicine ER -