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Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system.
Jpn J Med Sci Biol 1983; 36(1):17-25JJ

Abstract

Twenty-three rat lung specimens collected in outbreaks of hemorrhagic fever with renal syndrome (HFRS) in three medical institutions were inoculated onto the VERO-E6 cell monolayers. After several blind passages, an agent growing serially in the cell cultures and reacting specifically with known HFRS-positive sera was isolated from two of these specimens. The two isolates were antigenically identical each other. The agent, named strain SR-11, was identified as the causative virus of HFRS by its antigenic identity with E6 cell-adapted HFRS virus, Hantaan 76-118 strain, and the specific reactions with sera from various HFRS cases.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6134854

Citation

Kitamura, T, et al. "Isolation of Virus Causing Hemorrhagic Fever With Renal Syndrome (HFRS) Through a Cell Culture System." Japanese Journal of Medical Science & Biology, vol. 36, no. 1, 1983, pp. 17-25.
Kitamura T, Morita C, Komatsu T, et al. Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. Jpn J Med Sci Biol. 1983;36(1):17-25.
Kitamura, T., Morita, C., Komatsu, T., Sugiyama, K., Arikawa, J., Shiga, S., ... Urasawa, S. (1983). Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. Japanese Journal of Medical Science & Biology, 36(1), pp. 17-25.
Kitamura T, et al. Isolation of Virus Causing Hemorrhagic Fever With Renal Syndrome (HFRS) Through a Cell Culture System. Jpn J Med Sci Biol. 1983;36(1):17-25. PubMed PMID: 6134854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system. AU - Kitamura,T, AU - Morita,C, AU - Komatsu,T, AU - Sugiyama,K, AU - Arikawa,J, AU - Shiga,S, AU - Takeda,H, AU - Akao,Y, AU - Imaizumi,K, AU - Oya,A, AU - Hashimoto,N, AU - Urasawa,S, PY - 1983/2/1/pubmed PY - 1983/2/1/medline PY - 1983/2/1/entrez SP - 17 EP - 25 JF - Japanese journal of medical science & biology JO - Jpn. J. Med. Sci. Biol. VL - 36 IS - 1 N2 - Twenty-three rat lung specimens collected in outbreaks of hemorrhagic fever with renal syndrome (HFRS) in three medical institutions were inoculated onto the VERO-E6 cell monolayers. After several blind passages, an agent growing serially in the cell cultures and reacting specifically with known HFRS-positive sera was isolated from two of these specimens. The two isolates were antigenically identical each other. The agent, named strain SR-11, was identified as the causative virus of HFRS by its antigenic identity with E6 cell-adapted HFRS virus, Hantaan 76-118 strain, and the specific reactions with sera from various HFRS cases. SN - 0021-5112 UR - https://www.unboundmedicine.com/medline/citation/6134854/Isolation_of_virus_causing_hemorrhagic_fever_with_renal_syndrome__HFRS__through_a_cell_culture_system_ L2 - http://www.diseaseinfosearch.org/result/3317 DB - PRIME DP - Unbound Medicine ER -