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Gastric bicarbonate secretion in humans. Effect of pentagastrin, bethanechol, and 11,16,16-trimethyl prostaglandin E2.
J Clin Invest. 1983 Jul; 72(1):295-303.JCI

Abstract

Although the stomach is mainly known for its ability to secrete hydrochloric acid, there is increasing evidence that the gastric mucosa also secretes bicarbonate. A simple method for simultaneous measurement of gastric HCO-3 secretion and H+ secretion was developed from a two-component model of gastric secretion. The method, which is based upon gastric juice volume, H+ concentration, and osmolality, was validated both in vitro and in vivo. In 14 healthy human beings, basal gastric HCO-3 secretion averaged 2.6 mmol/h (range, 0.7-8.7 mmol/h). Basal HCO-3 secretion was approximately 50% of basal H+ secretion and there was a significant correlation between basal HCO-3 and H+ secretion in individual subjects (r = 0.79). HCO-3 was secreted in basal nonparietal secretion at a concentration of approximately 90 mmol/liter. Intravenous pentagastrin infusion markedly stimulated H+ secretion but did not increase HCO-3 secretion. During pentagastrin infusion, the cholinergic agonist, bethanechol, significantly augmented H+ secretion (from 20.2 to 24.7 mmol/h) and increased HCO-3 secretion (from 2.2 to 4.2 mmol/h). A prostaglandin E2 analogue significantly reduced H+ secretion and increased HCO-3 secretion during pentagastrin infusion. The reduction in net gastric juice H+ output following prostaglandin E2 was due more to H+ secretory inhibition than to HCO-3 secretory stimulation. We conclude that the healthy human stomach actively secretes HCO-3 and that gastric HCO-3 secretion can be influenced by cholinergic stimulation and by prostaglandin E2.

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Authors

Feldman M
No affiliation info available

MeSH

AdultBethanecholBethanechol CompoundsBicarbonatesDinoprostoneFemaleGastric AcidGastric JuiceGastric MucosaHumansHydrogen-Ion ConcentrationMaleMiddle AgedOsmolar ConcentrationPentagastrinProstaglandins E, Synthetic

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6135708

Citation

Feldman, M. "Gastric Bicarbonate Secretion in Humans. Effect of Pentagastrin, Bethanechol, and 11,16,16-trimethyl Prostaglandin E2." The Journal of Clinical Investigation, vol. 72, no. 1, 1983, pp. 295-303.
Feldman M. Gastric bicarbonate secretion in humans. Effect of pentagastrin, bethanechol, and 11,16,16-trimethyl prostaglandin E2. J Clin Invest. 1983;72(1):295-303.
Feldman, M. (1983). Gastric bicarbonate secretion in humans. Effect of pentagastrin, bethanechol, and 11,16,16-trimethyl prostaglandin E2. The Journal of Clinical Investigation, 72(1), 295-303.
Feldman M. Gastric Bicarbonate Secretion in Humans. Effect of Pentagastrin, Bethanechol, and 11,16,16-trimethyl Prostaglandin E2. J Clin Invest. 1983;72(1):295-303. PubMed PMID: 6135708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric bicarbonate secretion in humans. Effect of pentagastrin, bethanechol, and 11,16,16-trimethyl prostaglandin E2. A1 - Feldman,M, PY - 1983/7/1/pubmed PY - 1983/7/1/medline PY - 1983/7/1/entrez SP - 295 EP - 303 JF - The Journal of clinical investigation JO - J Clin Invest VL - 72 IS - 1 N2 - Although the stomach is mainly known for its ability to secrete hydrochloric acid, there is increasing evidence that the gastric mucosa also secretes bicarbonate. A simple method for simultaneous measurement of gastric HCO-3 secretion and H+ secretion was developed from a two-component model of gastric secretion. The method, which is based upon gastric juice volume, H+ concentration, and osmolality, was validated both in vitro and in vivo. In 14 healthy human beings, basal gastric HCO-3 secretion averaged 2.6 mmol/h (range, 0.7-8.7 mmol/h). Basal HCO-3 secretion was approximately 50% of basal H+ secretion and there was a significant correlation between basal HCO-3 and H+ secretion in individual subjects (r = 0.79). HCO-3 was secreted in basal nonparietal secretion at a concentration of approximately 90 mmol/liter. Intravenous pentagastrin infusion markedly stimulated H+ secretion but did not increase HCO-3 secretion. During pentagastrin infusion, the cholinergic agonist, bethanechol, significantly augmented H+ secretion (from 20.2 to 24.7 mmol/h) and increased HCO-3 secretion (from 2.2 to 4.2 mmol/h). A prostaglandin E2 analogue significantly reduced H+ secretion and increased HCO-3 secretion during pentagastrin infusion. The reduction in net gastric juice H+ output following prostaglandin E2 was due more to H+ secretory inhibition than to HCO-3 secretory stimulation. We conclude that the healthy human stomach actively secretes HCO-3 and that gastric HCO-3 secretion can be influenced by cholinergic stimulation and by prostaglandin E2. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/6135708/Gastric_bicarbonate_secretion_in_humans__Effect_of_pentagastrin_bethanechol_and_111616_trimethyl_prostaglandin_E2_ L2 - https://doi.org/10.1172/jci110969 DB - PRIME DP - Unbound Medicine ER -