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Neoplasia of the cervix uteri and contraception: a possible adverse effect of the pill.
Lancet. 1983 Oct 22; 2(8356):930-4.Lct

Abstract

The incidence of biopsy-proven cervical neoplasia during a 10-year follow-up was determined in 6838 parous women who entered the Oxford-Family Planning Association contraceptive study while using oral contraceptives and 3154 parous women who entered the study while using an intrauterine device (IUD). Risk factors for cervical neoplasia, continuation of attendance at family planning clinics, and frequency of examination by cervical cytology were similar in the two groups. All 13 cases of invasive cancer occurred in women in the oral contraceptive group; 9 had more than 6 years' use of the pill. Both carcinoma-in-situ and dysplasia also occurred more frequently in the oral contraceptive group than in the IUD group, and when the two conditions were considered together there was a trend in incidence with duration of oral contraceptive use. The incidence for all three forms of neoplasia combined rose from 0.9 per 1000 woman-years in those with up to 2 years' pill use to 2.2 per 1000 woman-years in those with more than 8 years' pill use. Amongst IUD users, there was no such trend in incidence with duration of use: the rate fluctuated around 1.0 per 1000 woman-years. The great majority of cases of invasive cancer were detected by means of cervical smears and were treated while the disease was still curable. Long-term users of oral contraceptives should have regular cervical cytological examination.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6138502

Citation

Vessey, M P., et al. "Neoplasia of the Cervix Uteri and Contraception: a Possible Adverse Effect of the Pill." Lancet (London, England), vol. 2, no. 8356, 1983, pp. 930-4.
Vessey MP, Lawless M, McPherson K, et al. Neoplasia of the cervix uteri and contraception: a possible adverse effect of the pill. Lancet. 1983;2(8356):930-4.
Vessey, M. P., Lawless, M., McPherson, K., & Yeates, D. (1983). Neoplasia of the cervix uteri and contraception: a possible adverse effect of the pill. Lancet (London, England), 2(8356), 930-4.
Vessey MP, et al. Neoplasia of the Cervix Uteri and Contraception: a Possible Adverse Effect of the Pill. Lancet. 1983 Oct 22;2(8356):930-4. PubMed PMID: 6138502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neoplasia of the cervix uteri and contraception: a possible adverse effect of the pill. AU - Vessey,M P, AU - Lawless,M, AU - McPherson,K, AU - Yeates,D, PY - 1983/10/22/pubmed PY - 1983/10/22/medline PY - 1983/10/22/entrez KW - Biology KW - Cancer KW - Cervical Cancer KW - Cervical Effects KW - Cervix KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--complications KW - Contraceptive Methods--side effects KW - Demographic Factors KW - Diseases KW - Family Planning KW - Genitalia KW - Genitalia, Female KW - Iud--complications KW - Neoplasms KW - Oral Contraceptives, Combined KW - Oral Contraceptives--side effects KW - Physiology KW - Population KW - Population Dynamics KW - Reproductive Control Agents KW - Time Factors KW - Urogenital System KW - Uterus SP - 930 EP - 4 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 8356 N2 - The incidence of biopsy-proven cervical neoplasia during a 10-year follow-up was determined in 6838 parous women who entered the Oxford-Family Planning Association contraceptive study while using oral contraceptives and 3154 parous women who entered the study while using an intrauterine device (IUD). Risk factors for cervical neoplasia, continuation of attendance at family planning clinics, and frequency of examination by cervical cytology were similar in the two groups. All 13 cases of invasive cancer occurred in women in the oral contraceptive group; 9 had more than 6 years' use of the pill. Both carcinoma-in-situ and dysplasia also occurred more frequently in the oral contraceptive group than in the IUD group, and when the two conditions were considered together there was a trend in incidence with duration of oral contraceptive use. The incidence for all three forms of neoplasia combined rose from 0.9 per 1000 woman-years in those with up to 2 years' pill use to 2.2 per 1000 woman-years in those with more than 8 years' pill use. Amongst IUD users, there was no such trend in incidence with duration of use: the rate fluctuated around 1.0 per 1000 woman-years. The great majority of cases of invasive cancer were detected by means of cervical smears and were treated while the disease was still curable. Long-term users of oral contraceptives should have regular cervical cytological examination. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/6138502/Neoplasia_of_the_cervix_uteri_and_contraception:_a_possible_adverse_effect_of_the_pill_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(83)90451-8 DB - PRIME DP - Unbound Medicine ER -