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Dissociated effects of somatostatin analogs on arginine-induced insulin, glucagon and growth hormone release in acromegalic patients.
Horm Metab Res. 1983 Oct; 15(10):471-4.HM

Abstract

Two analogs of somatostatin (Ala2,D-Trp8,D-Cys14-Somatostatin and L-5F-Trp8-Somatostatin) infused into acromegalics at the rate of 4.5 micrograms/min suppressed arginine-stimulated growth hormone release more strongly than 6 micrograms/min somatostatin (110 +/- 11% and 129 +/- 14%, respectively). Under the same conditions the two somatostatin analogs induced a much smaller inhibition of insulin (33 +/- 13% and 44 +/- 18%) and glucagon (28 +/- 10% and 45 +/- 17%, respectively) release than somatostatin did. Somatostatin analogs with dissociated actions could be promising for the treatment of diseases such as acromegaly, diabetes mellitus and some ectopic hormone syndromes.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6139329

Citation

Wajchenberg, B L., et al. "Dissociated Effects of Somatostatin Analogs On Arginine-induced Insulin, Glucagon and Growth Hormone Release in Acromegalic Patients." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 15, no. 10, 1983, pp. 471-4.
Wajchenberg BL, Cesar FP, Leme CE, et al. Dissociated effects of somatostatin analogs on arginine-induced insulin, glucagon and growth hormone release in acromegalic patients. Horm Metab Res. 1983;15(10):471-4.
Wajchenberg, B. L., Cesar, F. P., Leme, C. E., Borghi, V. C., Souza, V. C., Souza, I. T., Neto, D. G., Germek, O. A., Coy, D. H., & Comaru-Schally, A. M. (1983). Dissociated effects of somatostatin analogs on arginine-induced insulin, glucagon and growth hormone release in acromegalic patients. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 15(10), 471-4.
Wajchenberg BL, et al. Dissociated Effects of Somatostatin Analogs On Arginine-induced Insulin, Glucagon and Growth Hormone Release in Acromegalic Patients. Horm Metab Res. 1983;15(10):471-4. PubMed PMID: 6139329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dissociated effects of somatostatin analogs on arginine-induced insulin, glucagon and growth hormone release in acromegalic patients. A1 - Wajchenberg,B L, AU - Cesar,F P, AU - Leme,C E, AU - Borghi,V C, AU - Souza,V C, AU - Souza,I T, AU - Neto,D G, AU - Germek,O A, AU - Coy,D H, AU - Comaru-Schally,A M, PY - 1983/10/1/pubmed PY - 1983/10/1/medline PY - 1983/10/1/entrez SP - 471 EP - 4 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 15 IS - 10 N2 - Two analogs of somatostatin (Ala2,D-Trp8,D-Cys14-Somatostatin and L-5F-Trp8-Somatostatin) infused into acromegalics at the rate of 4.5 micrograms/min suppressed arginine-stimulated growth hormone release more strongly than 6 micrograms/min somatostatin (110 +/- 11% and 129 +/- 14%, respectively). Under the same conditions the two somatostatin analogs induced a much smaller inhibition of insulin (33 +/- 13% and 44 +/- 18%) and glucagon (28 +/- 10% and 45 +/- 17%, respectively) release than somatostatin did. Somatostatin analogs with dissociated actions could be promising for the treatment of diseases such as acromegaly, diabetes mellitus and some ectopic hormone syndromes. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/6139329/Dissociated_effects_of_somatostatin_analogs_on_arginine_induced_insulin_glucagon_and_growth_hormone_release_in_acromegalic_patients_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1018762 DB - PRIME DP - Unbound Medicine ER -