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Profound suppression of kindled seizures by cysteamine: possible role of somatostatin to kindled seizures.
Brain Res. 1983 Dec 12; 288(1-2):359-62.BR

Abstract

Recently we reported significant increase in immunoreactive somatostatin content in various brain regions of amygdaloid-kindled rats. We report here that acute intraperitoneal administration of cysteamine, an agent reported to deplete brain and gastrointestinal immunoreactive somatostatin content in kindled rats, led to profound suppression of kindled seizures. Purified anti-somatostatin antibody injected intracerebroventricularly also blocked the kindled seizures. The results show that endogenous immunoreactive somatostatin has a role in the development of seizures in amygdaloid kindled rats.

Authors

Higuchi T
No affiliation info available
Sikand GS
No affiliation info available
Kato N
No affiliation info available
Wada JA
No affiliation info available
Friesen HG
No affiliation info available

MeSH

AnimalsBrainCysteamineElectric StimulationKindling, NeurologicKineticsMaleRatsRats, Inbred StrainsSeizuresSomatostatin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6140981

Citation

Higuchi, T, et al. "Profound Suppression of Kindled Seizures By Cysteamine: Possible Role of Somatostatin to Kindled Seizures." Brain Research, vol. 288, no. 1-2, 1983, pp. 359-62.
Higuchi T, Sikand GS, Kato N, et al. Profound suppression of kindled seizures by cysteamine: possible role of somatostatin to kindled seizures. Brain Res. 1983;288(1-2):359-62.
Higuchi, T., Sikand, G. S., Kato, N., Wada, J. A., & Friesen, H. G. (1983). Profound suppression of kindled seizures by cysteamine: possible role of somatostatin to kindled seizures. Brain Research, 288(1-2), 359-62.
Higuchi T, et al. Profound Suppression of Kindled Seizures By Cysteamine: Possible Role of Somatostatin to Kindled Seizures. Brain Res. 1983 Dec 12;288(1-2):359-62. PubMed PMID: 6140981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Profound suppression of kindled seizures by cysteamine: possible role of somatostatin to kindled seizures. AU - Higuchi,T, AU - Sikand,G S, AU - Kato,N, AU - Wada,J A, AU - Friesen,H G, PY - 1983/12/12/pubmed PY - 1983/12/12/medline PY - 1983/12/12/entrez SP - 359 EP - 62 JF - Brain research JO - Brain Res VL - 288 IS - 1-2 N2 - Recently we reported significant increase in immunoreactive somatostatin content in various brain regions of amygdaloid-kindled rats. We report here that acute intraperitoneal administration of cysteamine, an agent reported to deplete brain and gastrointestinal immunoreactive somatostatin content in kindled rats, led to profound suppression of kindled seizures. Purified anti-somatostatin antibody injected intracerebroventricularly also blocked the kindled seizures. The results show that endogenous immunoreactive somatostatin has a role in the development of seizures in amygdaloid kindled rats. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/6140981/Profound_suppression_of_kindled_seizures_by_cysteamine:_possible_role_of_somatostatin_to_kindled_seizures_ DB - PRIME DP - Unbound Medicine ER -