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Immunisation of 4-6 month old Gambian infants with Edmonston-Zagreb measles vaccine.
Lancet. 1984 Oct 13; 2(8407):834-7.Lct

Abstract

Five different vaccination schedules were used to immunise Gambian infants aged 4-6 months against measles with the attenuated Edmonston-Zagreb strain of virus, which has a history of passage in human diploid cells. Vaccine aerosol given either by mask in a dose of 3500 or 7000 plaque-forming units (PFU) or from a plastic bag at a dose of 7000 PFU raised haemagglutinin-inhibiting or plaque-inhibiting measles antibody 16-24 weeks after vaccination to a titre of 1 in 8 or greater in all but 3 of the 51 children so vaccinated. All 21 infants given 11 400 PFU of vaccine intradermally in two divided doses and the 21 given 39 000 PFU of the virus subcutaneously also had satisfactory levels of measles antibody 16 weeks after vaccination. None of the vaccinated children had clinical evidence of measles in the 12 to 17 months after vaccination. The Edmonston-Zagreb vaccine, given subcutaneously or by other routes at 4-6 months, may be useful in preventing measles in infants in African cities, where 15-30% of children have measles before they are 9 months old, which is the recommended age for immunisation with the chick-cell-adapted strains of measles virus.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

6148572

Citation

Whittle, H C., et al. "Immunisation of 4-6 Month Old Gambian Infants With Edmonston-Zagreb Measles Vaccine." Lancet (London, England), vol. 2, no. 8407, 1984, pp. 834-7.
Whittle HC, Rowland MG, Mann GF, et al. Immunisation of 4-6 month old Gambian infants with Edmonston-Zagreb measles vaccine. Lancet. 1984;2(8407):834-7.
Whittle, H. C., Rowland, M. G., Mann, G. F., Lamb, W. H., & Lewis, R. A. (1984). Immunisation of 4-6 month old Gambian infants with Edmonston-Zagreb measles vaccine. Lancet (London, England), 2(8407), 834-7.
Whittle HC, et al. Immunisation of 4-6 Month Old Gambian Infants With Edmonston-Zagreb Measles Vaccine. Lancet. 1984 Oct 13;2(8407):834-7. PubMed PMID: 6148572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunisation of 4-6 month old Gambian infants with Edmonston-Zagreb measles vaccine. AU - Whittle,H C, AU - Rowland,M G, AU - Mann,G F, AU - Lamb,W H, AU - Lewis,R A, PY - 1984/10/13/pubmed PY - 1984/10/13/medline PY - 1984/10/13/entrez KW - Africa KW - Africa South Of The Sahara KW - Age Factors KW - Antibodies--analysis KW - Biology KW - Child KW - Delivery Of Health Care KW - Demographic Factors KW - Developing Countries KW - English Speaking Africa KW - Evaluation KW - Examinations And Diagnoses KW - Gambia KW - Health KW - Health Services KW - Immunity KW - Immunization KW - Immunologic Factors KW - Laboratory Examinations And Diagnoses KW - Laboratory Procedures KW - Medicine KW - Physiology KW - Population KW - Population Characteristics KW - Preventive Medicine KW - Primary Health Care KW - Vaccination--administraction and dosage KW - Western Africa KW - Youth SP - 834 EP - 7 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 8407 N2 - Five different vaccination schedules were used to immunise Gambian infants aged 4-6 months against measles with the attenuated Edmonston-Zagreb strain of virus, which has a history of passage in human diploid cells. Vaccine aerosol given either by mask in a dose of 3500 or 7000 plaque-forming units (PFU) or from a plastic bag at a dose of 7000 PFU raised haemagglutinin-inhibiting or plaque-inhibiting measles antibody 16-24 weeks after vaccination to a titre of 1 in 8 or greater in all but 3 of the 51 children so vaccinated. All 21 infants given 11 400 PFU of vaccine intradermally in two divided doses and the 21 given 39 000 PFU of the virus subcutaneously also had satisfactory levels of measles antibody 16 weeks after vaccination. None of the vaccinated children had clinical evidence of measles in the 12 to 17 months after vaccination. The Edmonston-Zagreb vaccine, given subcutaneously or by other routes at 4-6 months, may be useful in preventing measles in infants in African cities, where 15-30% of children have measles before they are 9 months old, which is the recommended age for immunisation with the chick-cell-adapted strains of measles virus. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/6148572/Immunisation_of_4_6_month_old_Gambian_infants_with_Edmonston_Zagreb_measles_vaccine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(84)90873-0 DB - PRIME DP - Unbound Medicine ER -