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Nasal and intrathalamic inoculations of primates with Tacaribe virus: protection against Argentine hemorrhagic fever and absence of neurovirulence.
Acta Virol. 1984 Jul; 28(4):277-81.AV

Abstract

Callithrix jacchus marmosets were inoculated by different routes with two stocks of Tacaribe virus, one from suckling mouse brain and another from human diploid MRC5 cells. All 12 primates inoculated by nasal route developed neutralizing serum antibodies without any clinical signs. All 6 primates receiving the mouse brain-Tacaribe virus were protected against lethal challenge with pathogenic XJ strain of Junin virus, while protection was also conferred in 4 out of 6 primates receiving the diploid cell-Tacaribe virus stock. Intramuscular (i.m.) inoculation also elicited antibodies and conferred protection to 4 primates receiving the diploid cell-virus stock. Intrathalamic (i.t.) inoculation of mouse brain-virus stock caused no clinical signs or histopathologic changes in groups of 3 primates each examined on days 33 and 90 post-infection (p.i.). All primates developed antibody response, but no virus could be detected in their brain. Thus, Tacaribe virus proved harmless and immunogenic in Callithrix jacchus and protected most marmosets against challenge with the lethal XJ strain of Junin virus.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6148851

Citation

Samoilovich, S R., et al. "Nasal and Intrathalamic Inoculations of Primates With Tacaribe Virus: Protection Against Argentine Hemorrhagic Fever and Absence of Neurovirulence." Acta Virologica, vol. 28, no. 4, 1984, pp. 277-81.
Samoilovich SR, Pecci Saavedra J, Frigerio MJ, et al. Nasal and intrathalamic inoculations of primates with Tacaribe virus: protection against Argentine hemorrhagic fever and absence of neurovirulence. Acta Virol. 1984;28(4):277-81.
Samoilovich, S. R., Pecci Saavedra, J., Frigerio, M. J., & Weissenbacher, M. C. (1984). Nasal and intrathalamic inoculations of primates with Tacaribe virus: protection against Argentine hemorrhagic fever and absence of neurovirulence. Acta Virologica, 28(4), 277-81.
Samoilovich SR, et al. Nasal and Intrathalamic Inoculations of Primates With Tacaribe Virus: Protection Against Argentine Hemorrhagic Fever and Absence of Neurovirulence. Acta Virol. 1984;28(4):277-81. PubMed PMID: 6148851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasal and intrathalamic inoculations of primates with Tacaribe virus: protection against Argentine hemorrhagic fever and absence of neurovirulence. AU - Samoilovich,S R, AU - Pecci Saavedra,J, AU - Frigerio,M J, AU - Weissenbacher,M C, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez SP - 277 EP - 81 JF - Acta virologica JO - Acta Virol VL - 28 IS - 4 N2 - Callithrix jacchus marmosets were inoculated by different routes with two stocks of Tacaribe virus, one from suckling mouse brain and another from human diploid MRC5 cells. All 12 primates inoculated by nasal route developed neutralizing serum antibodies without any clinical signs. All 6 primates receiving the mouse brain-Tacaribe virus were protected against lethal challenge with pathogenic XJ strain of Junin virus, while protection was also conferred in 4 out of 6 primates receiving the diploid cell-Tacaribe virus stock. Intramuscular (i.m.) inoculation also elicited antibodies and conferred protection to 4 primates receiving the diploid cell-virus stock. Intrathalamic (i.t.) inoculation of mouse brain-virus stock caused no clinical signs or histopathologic changes in groups of 3 primates each examined on days 33 and 90 post-infection (p.i.). All primates developed antibody response, but no virus could be detected in their brain. Thus, Tacaribe virus proved harmless and immunogenic in Callithrix jacchus and protected most marmosets against challenge with the lethal XJ strain of Junin virus. SN - 0001-723X UR - https://www.unboundmedicine.com/medline/citation/6148851/Nasal_and_intrathalamic_inoculations_of_primates_with_Tacaribe_virus:_protection_against_Argentine_hemorrhagic_fever_and_absence_of_neurovirulence_ DB - PRIME DP - Unbound Medicine ER -