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Intracellular study of effects of histamine on electrical behaviour of myenteric neurones in guinea-pig small intestine.
J Physiol. 1984 Oct; 355:411-25.JP

Abstract

The actions of histamine on myenteric neurones were investigated with intracellular recording methods in guinea-pig small intestine. The actions of histamine at the ganglion cell soma were: membrane depolarization, increased input resistance, suppression of post-spike hyperpolarizing potentials, augmented excitability and repetitive spike discharge. Excitability was enhanced also at spike initiation sites remote from the cell body. Both H1, and H2, receptors were involved in the response to histamine. Dimaprit mimicked the responses to histamine in 80% and 2-methylhistamine in 50% of the trials. Cimetidine was an antagonist for histamine in 82% and for dimaprit in all of the trials. Pyrilamine blocked the actions of histamine in 59% of the cells and always blocked the action of 2-methylhistamine. Histamine mimicked slow synaptic excitation in the neurones, but was ruled out as a neurotransmitter for the slow excitatory post-synaptic potential (e.p.s.p.). Histamine either did not affect the responses to 5-hydroxytryptamine, substance P and acetylcholine or it potentiated the responses to these putative neurotransmitters for slow synaptic excitation. The results support the possibility that histamine released from mast cells by circulating peptidergic messengers, by neurotransmitters or during anaphylaxis could influence enteric nervous function.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6149313

Citation

Nemeth, P R., et al. "Intracellular Study of Effects of Histamine On Electrical Behaviour of Myenteric Neurones in Guinea-pig Small Intestine." The Journal of Physiology, vol. 355, 1984, pp. 411-25.
Nemeth PR, Ort CA, Wood JD. Intracellular study of effects of histamine on electrical behaviour of myenteric neurones in guinea-pig small intestine. J Physiol. 1984;355:411-25.
Nemeth, P. R., Ort, C. A., & Wood, J. D. (1984). Intracellular study of effects of histamine on electrical behaviour of myenteric neurones in guinea-pig small intestine. The Journal of Physiology, 355, 411-25.
Nemeth PR, Ort CA, Wood JD. Intracellular Study of Effects of Histamine On Electrical Behaviour of Myenteric Neurones in Guinea-pig Small Intestine. J Physiol. 1984;355:411-25. PubMed PMID: 6149313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intracellular study of effects of histamine on electrical behaviour of myenteric neurones in guinea-pig small intestine. AU - Nemeth,P R, AU - Ort,C A, AU - Wood,J D, PY - 1984/10/1/pubmed PY - 1984/10/1/medline PY - 1984/10/1/entrez SP - 411 EP - 25 JF - The Journal of physiology JO - J Physiol VL - 355 N2 - The actions of histamine on myenteric neurones were investigated with intracellular recording methods in guinea-pig small intestine. The actions of histamine at the ganglion cell soma were: membrane depolarization, increased input resistance, suppression of post-spike hyperpolarizing potentials, augmented excitability and repetitive spike discharge. Excitability was enhanced also at spike initiation sites remote from the cell body. Both H1, and H2, receptors were involved in the response to histamine. Dimaprit mimicked the responses to histamine in 80% and 2-methylhistamine in 50% of the trials. Cimetidine was an antagonist for histamine in 82% and for dimaprit in all of the trials. Pyrilamine blocked the actions of histamine in 59% of the cells and always blocked the action of 2-methylhistamine. Histamine mimicked slow synaptic excitation in the neurones, but was ruled out as a neurotransmitter for the slow excitatory post-synaptic potential (e.p.s.p.). Histamine either did not affect the responses to 5-hydroxytryptamine, substance P and acetylcholine or it potentiated the responses to these putative neurotransmitters for slow synaptic excitation. The results support the possibility that histamine released from mast cells by circulating peptidergic messengers, by neurotransmitters or during anaphylaxis could influence enteric nervous function. SN - 0022-3751 UR - https://www.unboundmedicine.com/medline/citation/6149313/Intracellular_study_of_effects_of_histamine_on_electrical_behaviour_of_myenteric_neurones_in_guinea_pig_small_intestine_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3751&date=1984&volume=355&spage=411 DB - PRIME DP - Unbound Medicine ER -