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Inhibition of growth hormone and glucagon release by Phe-4-somatostatin in patients with acromegaly.
Res Commun Chem Pathol Pharmacol. 1984 Sep; 45(3):432-44.RC

Abstract

We have studied growth hormone (GH), insulin (I), glucagon (Gl) and glucose in basal conditions, after somatostatin (SS) (3 micrograms/ml) and Phe-4-SS (0.75 microgram/ml) infusion and IV bolus of the latter in 3 acromegalic patients. In two patients, Phe-4-SS inhibited glucagon and growth hormone secretion in a similar way as SS, without modifying insulin secretion. These effects were short-lived and ceased after the infusion was stopped. From these results it appears that Phe-4-SS is both more potent and more specific than SS with respect to inhibition of GH and glucagon release, but it does not have prolonged biological action. Lack of suppression of GH by SS or Phe-4-SS in the acromegalic patient with post-surgical recurrence of the disease could be due to the existence of receptor abnormalities, and suggests a diversity in the physiopathology of the disease.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6150529

Citation

Charro, A L., et al. "Inhibition of Growth Hormone and Glucagon Release By Phe-4-somatostatin in Patients With Acromegaly." Research Communications in Chemical Pathology and Pharmacology, vol. 45, no. 3, 1984, pp. 432-44.
Charro AL, Cabranes JA, Lafuente A, et al. Inhibition of growth hormone and glucagon release by Phe-4-somatostatin in patients with acromegaly. Res Commun Chem Pathol Pharmacol. 1984;45(3):432-44.
Charro, A. L., Cabranes, J. A., Lafuente, A., Diaz-Salgado, C., Cordero, M., Almoguera, I., Comaru-Schally, A. M., Meyers, C. A., Coy, D. H., & Schally, A. V. (1984). Inhibition of growth hormone and glucagon release by Phe-4-somatostatin in patients with acromegaly. Research Communications in Chemical Pathology and Pharmacology, 45(3), 432-44.
Charro AL, et al. Inhibition of Growth Hormone and Glucagon Release By Phe-4-somatostatin in Patients With Acromegaly. Res Commun Chem Pathol Pharmacol. 1984;45(3):432-44. PubMed PMID: 6150529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of growth hormone and glucagon release by Phe-4-somatostatin in patients with acromegaly. AU - Charro,A L, AU - Cabranes,J A, AU - Lafuente,A, AU - Diaz-Salgado,C, AU - Cordero,M, AU - Almoguera,I, AU - Comaru-Schally,A M, AU - Meyers,C A, AU - Coy,D H, AU - Schally,A V, PY - 1984/9/1/pubmed PY - 1984/9/1/medline PY - 1984/9/1/entrez SP - 432 EP - 44 JF - Research communications in chemical pathology and pharmacology JO - Res Commun Chem Pathol Pharmacol VL - 45 IS - 3 N2 - We have studied growth hormone (GH), insulin (I), glucagon (Gl) and glucose in basal conditions, after somatostatin (SS) (3 micrograms/ml) and Phe-4-SS (0.75 microgram/ml) infusion and IV bolus of the latter in 3 acromegalic patients. In two patients, Phe-4-SS inhibited glucagon and growth hormone secretion in a similar way as SS, without modifying insulin secretion. These effects were short-lived and ceased after the infusion was stopped. From these results it appears that Phe-4-SS is both more potent and more specific than SS with respect to inhibition of GH and glucagon release, but it does not have prolonged biological action. Lack of suppression of GH by SS or Phe-4-SS in the acromegalic patient with post-surgical recurrence of the disease could be due to the existence of receptor abnormalities, and suggests a diversity in the physiopathology of the disease. SN - 0034-5164 UR - https://www.unboundmedicine.com/medline/citation/6150529/Inhibition_of_growth_hormone_and_glucagon_release_by_Phe_4_somatostatin_in_patients_with_acromegaly_ L2 - http://www.diseaseinfosearch.org/result/162 DB - PRIME DP - Unbound Medicine ER -