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[Multiple endocrine neoplasms associated with Zollinger-Ellison syndrome and hyperparathyroidism].
Ann Gastroenterol Hepatol (Paris). 1984 Jul-Sep; 20(4):199-201.AG

Abstract

We report the case of a 43 year old man with multiple endocrine neoplasia (Zollinger-Ellison syndrome-hyperparathyroidism) diagnosed during investigations for a severe ulcer with diarrhoea. The history suggested Zollinger-Ellison syndrome, especially as basal acid production and blood gastrin levels were high. Hypercalcaemia and low blood phosphate levels suggested hyperparathyroidism, which was confirmed by ultra-sound of the neck, showing two parathyroid adenomas. The aim of treatment was two-fold: suppress the hyperparathyroidism and treat the Zollinger-Ellison syndrome. The approach is surgical in most cases, but the tumour is often impossible to remove and total gastrectomy has become rare with the progress in anti-secretory therapy. When the tumour behind a case of Zollinger-Ellison syndrome cannot be found, complementary chemotherapy is indicated. Other endocrine lesions must always be sought and the family investigated to exclude Wermer syndrome.

Authors

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Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

6152141

Citation

Tellaroli, J C., et al. "[Multiple Endocrine Neoplasms Associated With Zollinger-Ellison Syndrome and Hyperparathyroidism]." Annales De Gastroenterologie Et D'hepatologie, vol. 20, no. 4, 1984, pp. 199-201.
Tellaroli JC, Charleux H, Semin AM, et al. [Multiple endocrine neoplasms associated with Zollinger-Ellison syndrome and hyperparathyroidism]. Ann Gastroenterol Hepatol (Paris). 1984;20(4):199-201.
Tellaroli, J. C., Charleux, H., Semin, A. M., Parrot, B., Fasano, J. J., & Cain, P. (1984). [Multiple endocrine neoplasms associated with Zollinger-Ellison syndrome and hyperparathyroidism]. Annales De Gastroenterologie Et D'hepatologie, 20(4), 199-201.
Tellaroli JC, et al. [Multiple Endocrine Neoplasms Associated With Zollinger-Ellison Syndrome and Hyperparathyroidism]. Ann Gastroenterol Hepatol (Paris). 1984 Jul-Sep;20(4):199-201. PubMed PMID: 6152141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Multiple endocrine neoplasms associated with Zollinger-Ellison syndrome and hyperparathyroidism]. AU - Tellaroli,J C, AU - Charleux,H, AU - Semin,A M, AU - Parrot,B, AU - Fasano,J J, AU - Cain,P, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez SP - 199 EP - 201 JF - Annales de gastroenterologie et d'hepatologie JO - Ann Gastroenterol Hepatol (Paris) VL - 20 IS - 4 N2 - We report the case of a 43 year old man with multiple endocrine neoplasia (Zollinger-Ellison syndrome-hyperparathyroidism) diagnosed during investigations for a severe ulcer with diarrhoea. The history suggested Zollinger-Ellison syndrome, especially as basal acid production and blood gastrin levels were high. Hypercalcaemia and low blood phosphate levels suggested hyperparathyroidism, which was confirmed by ultra-sound of the neck, showing two parathyroid adenomas. The aim of treatment was two-fold: suppress the hyperparathyroidism and treat the Zollinger-Ellison syndrome. The approach is surgical in most cases, but the tumour is often impossible to remove and total gastrectomy has become rare with the progress in anti-secretory therapy. When the tumour behind a case of Zollinger-Ellison syndrome cannot be found, complementary chemotherapy is indicated. Other endocrine lesions must always be sought and the family investigated to exclude Wermer syndrome. SN - 0066-2070 UR - https://www.unboundmedicine.com/medline/citation/6152141/[Multiple_endocrine_neoplasms_associated_with_Zollinger_Ellison_syndrome_and_hyperparathyroidism]_ L2 - http://www.diseaseinfosearch.org/result/7600 DB - PRIME DP - Unbound Medicine ER -