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Relationship between protective activity and antigen structure of Haemophilus paragallinarum serotypes 1 and 2.

Abstract

The object in this investigation was to determine the relationship between protective activity and antigenic structure of Haemophilus paragallinarum, serotypes 1 and 2. A close relationship exists in both serotypes between protective activity and colonial phenotypic form (iridescent and noniridescent). Protective activities of both serotypes were related to a heat-labile, trypsin-sensitive (L) antigen of iridescent form that produced serotype-specific agglutinin to chickens. The chickens having the agglutinins were protected against challenge exposure with homologous strain, but not with heterologous strain. The chickens injected with unencapsulated organisms of noniridescent form that were derived from encapsulated organisms of iridescent form failed to produce both serotype-specific agglutinins and protection against challenge exposure with homologous strain. Most of the chickens injected with serotype 1 strain produced both hemagglutination-inhibition antibody and serotype 1-specific agglutinin, whereas those injected with serotype 2 produced serotype 2-specific agglutinin and protected against homologous challenge exposure. The protective activity was found in saline extract derived from encapsulated organisms of serotype 1, but was absent in those of serotype 2.

Authors

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Source

MeSH

Agglutination Tests
Animals
Antibody Formation
Chickens
Epitopes
Haemophilus
Haemophilus Infections
Hemagglutination Inhibition Tests
Immunization
Poultry Diseases
Serotyping

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6153875

Citation

Kume, K, et al. "Relationship Between Protective Activity and Antigen Structure of Haemophilus Paragallinarum Serotypes 1 and 2." American Journal of Veterinary Research, vol. 41, no. 1, 1980, pp. 97-100.
Kume K, Sawata A, Nakase Y. Relationship between protective activity and antigen structure of Haemophilus paragallinarum serotypes 1 and 2. Am J Vet Res. 1980;41(1):97-100.
Kume, K., Sawata, A., & Nakase, Y. (1980). Relationship between protective activity and antigen structure of Haemophilus paragallinarum serotypes 1 and 2. American Journal of Veterinary Research, 41(1), pp. 97-100.
Kume K, Sawata A, Nakase Y. Relationship Between Protective Activity and Antigen Structure of Haemophilus Paragallinarum Serotypes 1 and 2. Am J Vet Res. 1980;41(1):97-100. PubMed PMID: 6153875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between protective activity and antigen structure of Haemophilus paragallinarum serotypes 1 and 2. AU - Kume,K, AU - Sawata,A, AU - Nakase,Y, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 97 EP - 100 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 41 IS - 1 N2 - The object in this investigation was to determine the relationship between protective activity and antigenic structure of Haemophilus paragallinarum, serotypes 1 and 2. A close relationship exists in both serotypes between protective activity and colonial phenotypic form (iridescent and noniridescent). Protective activities of both serotypes were related to a heat-labile, trypsin-sensitive (L) antigen of iridescent form that produced serotype-specific agglutinin to chickens. The chickens having the agglutinins were protected against challenge exposure with homologous strain, but not with heterologous strain. The chickens injected with unencapsulated organisms of noniridescent form that were derived from encapsulated organisms of iridescent form failed to produce both serotype-specific agglutinins and protection against challenge exposure with homologous strain. Most of the chickens injected with serotype 1 strain produced both hemagglutination-inhibition antibody and serotype 1-specific agglutinin, whereas those injected with serotype 2 produced serotype 2-specific agglutinin and protected against homologous challenge exposure. The protective activity was found in saline extract derived from encapsulated organisms of serotype 1, but was absent in those of serotype 2. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/6153875/Relationship_between_protective_activity_and_antigen_structure_of_Haemophilus_paragallinarum_serotypes_1_and_2_ DB - PRIME DP - Unbound Medicine ER -