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Peptide length requirement for experimental allergic encephalomyelitis in guinea pigs.
Neurochem Res. 1980 Jan; 5(1):37-42.NR

Abstract

Three peptides overlapping the tryptophan region of bovine CNS myelin basic protein were synthesized by the solid phase procedure of Merrifield. These were the nonapeptide H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, the octapeptide H-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, and the heptapeptide H-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH. They were tested for encephalitogenic activity in guinea pigs with either Freund's complete adjuvant containing M. tuberculosis or muramyl dipeptide in incomplete Freund's adjuvant at doses of 10 microgram per animal. The results show that deletion of one or two residues from the amino-terminal end of the nonapeptide destroyed the ability of the shorter peptides to induce clinical but not histological signs of EAE.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6154250

Citation

Levit, S, et al. "Peptide Length Requirement for Experimental Allergic Encephalomyelitis in Guinea Pigs." Neurochemical Research, vol. 5, no. 1, 1980, pp. 37-42.
Levit S, Powers JM, Milek D, et al. Peptide length requirement for experimental allergic encephalomyelitis in guinea pigs. Neurochem Res. 1980;5(1):37-42.
Levit, S., Powers, J. M., Milek, D., & Brostoff, S. W. (1980). Peptide length requirement for experimental allergic encephalomyelitis in guinea pigs. Neurochemical Research, 5(1), 37-42.
Levit S, et al. Peptide Length Requirement for Experimental Allergic Encephalomyelitis in Guinea Pigs. Neurochem Res. 1980;5(1):37-42. PubMed PMID: 6154250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peptide length requirement for experimental allergic encephalomyelitis in guinea pigs. AU - Levit,S, AU - Powers,J M, AU - Milek,D, AU - Brostoff,S W, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 37 EP - 42 JF - Neurochemical research JO - Neurochem Res VL - 5 IS - 1 N2 - Three peptides overlapping the tryptophan region of bovine CNS myelin basic protein were synthesized by the solid phase procedure of Merrifield. These were the nonapeptide H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, the octapeptide H-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH, and the heptapeptide H-Trp-Gly-Ala-Glu-Gly-Gln-Lys-OH. They were tested for encephalitogenic activity in guinea pigs with either Freund's complete adjuvant containing M. tuberculosis or muramyl dipeptide in incomplete Freund's adjuvant at doses of 10 microgram per animal. The results show that deletion of one or two residues from the amino-terminal end of the nonapeptide destroyed the ability of the shorter peptides to induce clinical but not histological signs of EAE. SN - 0364-3190 UR - https://www.unboundmedicine.com/medline/citation/6154250/Peptide_length_requirement_for_experimental_allergic_encephalomyelitis_in_guinea_pigs_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6154250 DB - PRIME DP - Unbound Medicine ER -