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Lymphatic tissue in Argentine hemorrhagic fever. Pathologic features.
Arch Pathol Lab Med. 1980 May; 104(5):250-4.AP

Abstract

Spleen and lymph nodes from seven fatal cases of Argentine hemorrhagic fever were studied by light and electron microscopy and by immunofluorescent techniques. In addition, Junin virus infectivity was determined. Destruction of splenic white pulp and of lymph node cortex was observed. The ultrastructural study showed a characteristic cytopathic effect on the macrophages with presence of intracisternal virus-like particles and occasional virions budding from the plasma membrane. The immunofluorescent techniques indicated the presence of Junin virus antigenic determinants in the cytoplasm of macrophages in the examined organs. Junin virus titers were three times higher than in peripheral blood. These results suggest that lymphatic tissue is one of the main sites of viral replication and that the macrophages are the targets of Junin virus.

Authors

González PH
No affiliation info available
Cossio PM
No affiliation info available
Arana R
No affiliation info available
Maiztegui JI
No affiliation info available
Laguens RP
No affiliation info available

MeSH

Antigens, ViralArenaviruses, New WorldCytopathogenic Effect, ViralEpitopesFluorescent Antibody TechniqueHemorrhagic Fever, AmericanHumansLymph NodesMicroscopy, ElectronSpleenVirion

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6154445

Citation

González, P H., et al. "Lymphatic Tissue in Argentine Hemorrhagic Fever. Pathologic Features." Archives of Pathology & Laboratory Medicine, vol. 104, no. 5, 1980, pp. 250-4.
González PH, Cossio PM, Arana R, et al. Lymphatic tissue in Argentine hemorrhagic fever. Pathologic features. Arch Pathol Lab Med. 1980;104(5):250-4.
González, P. H., Cossio, P. M., Arana, R., Maiztegui, J. I., & Laguens, R. P. (1980). Lymphatic tissue in Argentine hemorrhagic fever. Pathologic features. Archives of Pathology & Laboratory Medicine, 104(5), 250-4.
González PH, et al. Lymphatic Tissue in Argentine Hemorrhagic Fever. Pathologic Features. Arch Pathol Lab Med. 1980;104(5):250-4. PubMed PMID: 6154445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymphatic tissue in Argentine hemorrhagic fever. Pathologic features. AU - González,P H, AU - Cossio,P M, AU - Arana,R, AU - Maiztegui,J I, AU - Laguens,R P, PY - 1980/5/1/pubmed PY - 1980/5/1/medline PY - 1980/5/1/entrez SP - 250 EP - 4 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 104 IS - 5 N2 - Spleen and lymph nodes from seven fatal cases of Argentine hemorrhagic fever were studied by light and electron microscopy and by immunofluorescent techniques. In addition, Junin virus infectivity was determined. Destruction of splenic white pulp and of lymph node cortex was observed. The ultrastructural study showed a characteristic cytopathic effect on the macrophages with presence of intracisternal virus-like particles and occasional virions budding from the plasma membrane. The immunofluorescent techniques indicated the presence of Junin virus antigenic determinants in the cytoplasm of macrophages in the examined organs. Junin virus titers were three times higher than in peripheral blood. These results suggest that lymphatic tissue is one of the main sites of viral replication and that the macrophages are the targets of Junin virus. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/6154445/Lymphatic_tissue_in_Argentine_hemorrhagic_fever__Pathologic_features_ L2 - http://www.diseaseinfosearch.org/result/3317 DB - PRIME DP - Unbound Medicine ER -