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Histamine release induced from rat mast cells by the ionophore A23187 in the absence of extracellular calcium.
Eur J Pharmacol. 1980 Apr 04; 62(4):329-34.EJ

Abstract

Isolated rat mast cells were used to study whether ionophore A23187 could induce histamine release by mobilizing cellular calcium. The histamine release was a slow process which was completed after about 20 min incubation with A23187. The A23187-induced histamine release was inhibited after incubation of the cells with EDTA for 1 h in a 37 degrees C water bath in calcium-free medium. Reintroduction of calcium in excess of EDTA induced the release of histamine. The observations suggest that A23187 can induce histamine release by mobilizing a cellular pool of calcium.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6154590

Citation

Johansen, T. "Histamine Release Induced From Rat Mast Cells By the Ionophore A23187 in the Absence of Extracellular Calcium." European Journal of Pharmacology, vol. 62, no. 4, 1980, pp. 329-34.
Johansen T. Histamine release induced from rat mast cells by the ionophore A23187 in the absence of extracellular calcium. Eur J Pharmacol. 1980;62(4):329-34.
Johansen, T. (1980). Histamine release induced from rat mast cells by the ionophore A23187 in the absence of extracellular calcium. European Journal of Pharmacology, 62(4), 329-34.
Johansen T. Histamine Release Induced From Rat Mast Cells By the Ionophore A23187 in the Absence of Extracellular Calcium. Eur J Pharmacol. 1980 Apr 4;62(4):329-34. PubMed PMID: 6154590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine release induced from rat mast cells by the ionophore A23187 in the absence of extracellular calcium. A1 - Johansen,T, PY - 1980/4/4/pubmed PY - 1980/4/4/medline PY - 1980/4/4/entrez SP - 329 EP - 34 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 62 IS - 4 N2 - Isolated rat mast cells were used to study whether ionophore A23187 could induce histamine release by mobilizing cellular calcium. The histamine release was a slow process which was completed after about 20 min incubation with A23187. The A23187-induced histamine release was inhibited after incubation of the cells with EDTA for 1 h in a 37 degrees C water bath in calcium-free medium. Reintroduction of calcium in excess of EDTA induced the release of histamine. The observations suggest that A23187 can induce histamine release by mobilizing a cellular pool of calcium. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/6154590/Histamine_release_induced_from_rat_mast_cells_by_the_ionophore_A23187_in_the_absence_of_extracellular_calcium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(80)90100-4 DB - PRIME DP - Unbound Medicine ER -