Tags

Type your tag names separated by a space and hit enter

Regulation of experimental allergic encephalomyelitis. II. Appearance of suppressor cells during the remission phase of the disease.
J Immunol. 1980 Jul; 125(1):186-9.JI

Abstract

Lewis rats are susceptible to experimental autoimmune encephalomyelitis (EAE). Most rats recover from paralysis and are subsequently resistant to the disease. In an adoptive transfer system, we found that lymph node cells (LNC) from rats that had recovered from EAE protect syngeneic recipients from the disease when the latter are challenged with encephalitogenic myelin basic protein and adjuvant after receiving donor cells. Suppression is antigen-specific and requires viable LNC. In contrast to the suppressor cells we previously studied in tolerized rats, which were nonadherent T lymphocytes, the suppressor cells found in rats that have recovered from EAE adhere to glass wool. However, they are not retained on Sephadex G-10 columns to which macrophages adhere. Suppressor activity is enriched in the nylon wool-adherent LNC population (which consists of approximately 80% Ig+ cells). Our findings suggest that activation of adherent suppressor cells may be implicated in recovery from EAE. These may be adherent T cells, or B cells that produce anti-BP blocking antibodies.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6155396

Citation

Welch, A M., et al. "Regulation of Experimental Allergic Encephalomyelitis. II. Appearance of Suppressor Cells During the Remission Phase of the Disease." Journal of Immunology (Baltimore, Md. : 1950), vol. 125, no. 1, 1980, pp. 186-9.
Welch AM, Holda JH, Swanborg RH. Regulation of experimental allergic encephalomyelitis. II. Appearance of suppressor cells during the remission phase of the disease. J Immunol. 1980;125(1):186-9.
Welch, A. M., Holda, J. H., & Swanborg, R. H. (1980). Regulation of experimental allergic encephalomyelitis. II. Appearance of suppressor cells during the remission phase of the disease. Journal of Immunology (Baltimore, Md. : 1950), 125(1), 186-9.
Welch AM, Holda JH, Swanborg RH. Regulation of Experimental Allergic Encephalomyelitis. II. Appearance of Suppressor Cells During the Remission Phase of the Disease. J Immunol. 1980;125(1):186-9. PubMed PMID: 6155396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of experimental allergic encephalomyelitis. II. Appearance of suppressor cells during the remission phase of the disease. AU - Welch,A M, AU - Holda,J H, AU - Swanborg,R H, PY - 1980/7/1/pubmed PY - 1980/7/1/medline PY - 1980/7/1/entrez SP - 186 EP - 9 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 125 IS - 1 N2 - Lewis rats are susceptible to experimental autoimmune encephalomyelitis (EAE). Most rats recover from paralysis and are subsequently resistant to the disease. In an adoptive transfer system, we found that lymph node cells (LNC) from rats that had recovered from EAE protect syngeneic recipients from the disease when the latter are challenged with encephalitogenic myelin basic protein and adjuvant after receiving donor cells. Suppression is antigen-specific and requires viable LNC. In contrast to the suppressor cells we previously studied in tolerized rats, which were nonadherent T lymphocytes, the suppressor cells found in rats that have recovered from EAE adhere to glass wool. However, they are not retained on Sephadex G-10 columns to which macrophages adhere. Suppressor activity is enriched in the nylon wool-adherent LNC population (which consists of approximately 80% Ig+ cells). Our findings suggest that activation of adherent suppressor cells may be implicated in recovery from EAE. These may be adherent T cells, or B cells that produce anti-BP blocking antibodies. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/6155396/Regulation_of_experimental_allergic_encephalomyelitis__II__Appearance_of_suppressor_cells_during_the_remission_phase_of_the_disease_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=6155396 DB - PRIME DP - Unbound Medicine ER -