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The rationale of photocoagulation therapy for proliferative diabetic retinopathy: a review and a model.
Ophthalmic Surg. 1980 Apr; 11(4):235-45.OS

Abstract

A model is proposed for initiation and inhibition of growth in retinal vessels including the control of proliferative diabetic retinopathy by photocoagulation. The model assumes that chronic dilatation (constriction) of a retinal blood vessel causes (inhibits) growth. Destruction of rods and cones by photocoagulation allows more choroidal oxygen to reach the inner retina and constrict retinal vessels. The attenuated vessels in late stage retinitis pigmentosa are an analogous and exaggerated effect to that from photocoagulation. The control of proliferative diabetic retinopathy is compared to the cause of retrolental fibroplasma. Following vitrectomy the retina utilizes oxygen from the aqueous which results in dilatation of iris vessels followed by rubeosis iridis. From this model, neovascularization from the disc or angle vessels follows the dilatation resulting from increased flow in their distal vascular beds.

Authors

Wolbarsht ML
No affiliation info available
Landers MB
No affiliation info available

MeSH

Diabetic RetinopathyHumansLaser TherapyLight CoagulationModels, BiologicalNeovascularization, PathologicOxygen ConsumptionRetinaRetinal VesselsRetinitis PigmentosaVitreous Body

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

6155650

Citation

Wolbarsht, M L., and M B. Landers. "The Rationale of Photocoagulation Therapy for Proliferative Diabetic Retinopathy: a Review and a Model." Ophthalmic Surgery, vol. 11, no. 4, 1980, pp. 235-45.
Wolbarsht ML, Landers MB. The rationale of photocoagulation therapy for proliferative diabetic retinopathy: a review and a model. Ophthalmic Surg. 1980;11(4):235-45.
Wolbarsht, M. L., & Landers, M. B. (1980). The rationale of photocoagulation therapy for proliferative diabetic retinopathy: a review and a model. Ophthalmic Surgery, 11(4), 235-45.
Wolbarsht ML, Landers MB. The Rationale of Photocoagulation Therapy for Proliferative Diabetic Retinopathy: a Review and a Model. Ophthalmic Surg. 1980;11(4):235-45. PubMed PMID: 6155650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The rationale of photocoagulation therapy for proliferative diabetic retinopathy: a review and a model. AU - Wolbarsht,M L, AU - Landers,M B,3rd PY - 1980/4/1/pubmed PY - 1980/4/1/medline PY - 1980/4/1/entrez SP - 235 EP - 45 JF - Ophthalmic surgery JO - Ophthalmic Surg VL - 11 IS - 4 N2 - A model is proposed for initiation and inhibition of growth in retinal vessels including the control of proliferative diabetic retinopathy by photocoagulation. The model assumes that chronic dilatation (constriction) of a retinal blood vessel causes (inhibits) growth. Destruction of rods and cones by photocoagulation allows more choroidal oxygen to reach the inner retina and constrict retinal vessels. The attenuated vessels in late stage retinitis pigmentosa are an analogous and exaggerated effect to that from photocoagulation. The control of proliferative diabetic retinopathy is compared to the cause of retrolental fibroplasma. Following vitrectomy the retina utilizes oxygen from the aqueous which results in dilatation of iris vessels followed by rubeosis iridis. From this model, neovascularization from the disc or angle vessels follows the dilatation resulting from increased flow in their distal vascular beds. SN - 0022-023X UR - https://www.unboundmedicine.com/medline/citation/6155650/The_rationale_of_photocoagulation_therapy_for_proliferative_diabetic_retinopathy:_a_review_and_a_model_ L2 - https://medlineplus.gov/diabeticeyeproblems.html DB - PRIME DP - Unbound Medicine ER -