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Effect of sensitization and non-antibody IgE on 48/80 induced histamine release from isolated rat mast cells.
Acta Physiol Scand. 1980 Jun; 109(2):131-6.AP

Abstract

Histamine release from isolated rat mast cells from non-immunized and immunized Hooded Lister rats was induced by compound 48/80. The histamine release was decreased with a lower maximum at the optimal concentration of 48/80 when using cells from immunized rats compared to non-immunized control rats. The stimulation of IgE antibody production, after immunization using B. pertussis as an adjuvant was also accompanied by an elevation of total serum IgW. The 48/80 induced histamine release from Sprague Dawley mast cells was not inhibited by immunization. Non-antibody IgE showed a non-competitive inhibition of 48/80 induced histamine release when myeloma IgE was incubated with mast cells from both Hooded Lister and Sprague Dawley rats. The results indicate the existence of different receptors for IgE and 48/80.

Authors

Sydbom A
No affiliation info available
Karlsson T
No affiliation info available
Uvnäs B
No affiliation info available

MeSH

AnimalsDose-Response Relationship, DrugHistamine ReleaseImmunizationImmunoglobulin EIn Vitro TechniquesMaleMast CellsRatsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6158831

Citation

Sydbom, A, et al. "Effect of Sensitization and Non-antibody IgE On 48/80 Induced Histamine Release From Isolated Rat Mast Cells." Acta Physiologica Scandinavica, vol. 109, no. 2, 1980, pp. 131-6.
Sydbom A, Karlsson T, Uvnäs B. Effect of sensitization and non-antibody IgE on 48/80 induced histamine release from isolated rat mast cells. Acta Physiol Scand. 1980;109(2):131-6.
Sydbom, A., Karlsson, T., & Uvnäs, B. (1980). Effect of sensitization and non-antibody IgE on 48/80 induced histamine release from isolated rat mast cells. Acta Physiologica Scandinavica, 109(2), 131-6.
Sydbom A, Karlsson T, Uvnäs B. Effect of Sensitization and Non-antibody IgE On 48/80 Induced Histamine Release From Isolated Rat Mast Cells. Acta Physiol Scand. 1980;109(2):131-6. PubMed PMID: 6158831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of sensitization and non-antibody IgE on 48/80 induced histamine release from isolated rat mast cells. AU - Sydbom,A, AU - Karlsson,T, AU - Uvnäs,B, PY - 1980/6/1/pubmed PY - 1980/6/1/medline PY - 1980/6/1/entrez SP - 131 EP - 6 JF - Acta physiologica Scandinavica JO - Acta Physiol Scand VL - 109 IS - 2 N2 - Histamine release from isolated rat mast cells from non-immunized and immunized Hooded Lister rats was induced by compound 48/80. The histamine release was decreased with a lower maximum at the optimal concentration of 48/80 when using cells from immunized rats compared to non-immunized control rats. The stimulation of IgE antibody production, after immunization using B. pertussis as an adjuvant was also accompanied by an elevation of total serum IgW. The 48/80 induced histamine release from Sprague Dawley mast cells was not inhibited by immunization. Non-antibody IgE showed a non-competitive inhibition of 48/80 induced histamine release when myeloma IgE was incubated with mast cells from both Hooded Lister and Sprague Dawley rats. The results indicate the existence of different receptors for IgE and 48/80. SN - 0001-6772 UR - https://www.unboundmedicine.com/medline/citation/6158831/Effect_of_sensitization_and_non_antibody_IgE_on_48/80_induced_histamine_release_from_isolated_rat_mast_cells_ L2 - https://doi.org/10.1111/j.1748-1716.1980.tb06577.x DB - PRIME DP - Unbound Medicine ER -