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Further observations on the utilization of adenosine triphosphate in rat mast cells during histamine release induced by the ionophore A23187.
Br J Pharmacol. 1980 Aug; 69(4):657-62.BJ

Abstract

1 The relation between A23187-induced histamine release and the energy metabolism of the rat mast cells has been studied. 2 Ethacrynic acid was used as an inhibitor of calcium-induced histamine release from mast cells primed with the ionophore A23187, and to study calcium-induced changes in the adenosine triphosphate (ATP) content and the rate of lactate production of A23187-primed mast cells. 3 Ethacrynic acid by itself decreased the rate of glycolytic ATP production. 4 By measurement of the ATP content and the lactate production of mast cells with or without secretory activity, the increased demand of energy for exocytosis was estimated to be equivalent to 0.14 pmol of ATP pr 10(3) mast cells.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6159939

Citation

Johansen, T. "Further Observations On the Utilization of Adenosine Triphosphate in Rat Mast Cells During Histamine Release Induced By the Ionophore A23187." British Journal of Pharmacology, vol. 69, no. 4, 1980, pp. 657-62.
Johansen T. Further observations on the utilization of adenosine triphosphate in rat mast cells during histamine release induced by the ionophore A23187. Br J Pharmacol. 1980;69(4):657-62.
Johansen, T. (1980). Further observations on the utilization of adenosine triphosphate in rat mast cells during histamine release induced by the ionophore A23187. British Journal of Pharmacology, 69(4), 657-62.
Johansen T. Further Observations On the Utilization of Adenosine Triphosphate in Rat Mast Cells During Histamine Release Induced By the Ionophore A23187. Br J Pharmacol. 1980;69(4):657-62. PubMed PMID: 6159939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further observations on the utilization of adenosine triphosphate in rat mast cells during histamine release induced by the ionophore A23187. A1 - Johansen,T, PY - 1980/8/1/pubmed PY - 1980/8/1/medline PY - 1980/8/1/entrez SP - 657 EP - 62 JF - British journal of pharmacology JO - Br J Pharmacol VL - 69 IS - 4 N2 - 1 The relation between A23187-induced histamine release and the energy metabolism of the rat mast cells has been studied. 2 Ethacrynic acid was used as an inhibitor of calcium-induced histamine release from mast cells primed with the ionophore A23187, and to study calcium-induced changes in the adenosine triphosphate (ATP) content and the rate of lactate production of A23187-primed mast cells. 3 Ethacrynic acid by itself decreased the rate of glycolytic ATP production. 4 By measurement of the ATP content and the lactate production of mast cells with or without secretory activity, the increased demand of energy for exocytosis was estimated to be equivalent to 0.14 pmol of ATP pr 10(3) mast cells. SN - 0007-1188 UR - https://www.unboundmedicine.com/medline/citation/6159939/Further_observations_on_the_utilization_of_adenosine_triphosphate_in_rat_mast_cells_during_histamine_release_induced_by_the_ionophore_A23187_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1188&date=1980&volume=69&issue=4&spage=657 DB - PRIME DP - Unbound Medicine ER -