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Relations between serum levels of TSH, TBG, T4, T3, rT3 and various histologically classified chronic liver diseases.
J Endocrinol Invest. 1980 Oct-Dec; 3(4):379-83.JE

Abstract

Serum levels of TSH, thyroxine-binding globulin (TBG), T4, T3 and reverse T3 (rT3) were measured in 36 patients with fatty liver disease, 11 patients wih chronic persistent hepatitis, 17 patients with chronic active hepatitis, and 29 patients with liver cirrhosis. TBG was significantly above normal levels in both groups of chronic hepatitis, the slight concomitant T4 and T3 increase was significant only for T4 in chronic persistent hepatitis. A significant decrease in T4 and T3 concentration was found in fatty liver disease and in hepatic cirrhosis. A shift in T4 conversion to rT3 could exclusively be demonstrated for the group of hepatic cirrhosis, reflected by a significant increase in rT3. As our findings indicate normal TSH levels and a lack of clinical signs of hypothyroidism in chronic liver disease, the possibility of diverse regulating changes must be considered.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6162877

Citation

L'age, M, et al. "Relations Between Serum Levels of TSH, TBG, T4, T3, rT3 and Various Histologically Classified Chronic Liver Diseases." Journal of Endocrinological Investigation, vol. 3, no. 4, 1980, pp. 379-83.
L'age M, Meinhold H, Wenzel KW, et al. Relations between serum levels of TSH, TBG, T4, T3, rT3 and various histologically classified chronic liver diseases. J Endocrinol Invest. 1980;3(4):379-83.
L'age, M., Meinhold, H., Wenzel, K. W., & Schleusener, H. (1980). Relations between serum levels of TSH, TBG, T4, T3, rT3 and various histologically classified chronic liver diseases. Journal of Endocrinological Investigation, 3(4), 379-83.
L'age M, et al. Relations Between Serum Levels of TSH, TBG, T4, T3, rT3 and Various Histologically Classified Chronic Liver Diseases. J Endocrinol Invest. 1980 Oct-Dec;3(4):379-83. PubMed PMID: 6162877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relations between serum levels of TSH, TBG, T4, T3, rT3 and various histologically classified chronic liver diseases. AU - L'age,M, AU - Meinhold,H, AU - Wenzel,K W, AU - Schleusener,H, PY - 1980/10/1/pubmed PY - 1980/10/1/medline PY - 1980/10/1/entrez SP - 379 EP - 83 JF - Journal of endocrinological investigation JO - J. Endocrinol. Invest. VL - 3 IS - 4 N2 - Serum levels of TSH, thyroxine-binding globulin (TBG), T4, T3 and reverse T3 (rT3) were measured in 36 patients with fatty liver disease, 11 patients wih chronic persistent hepatitis, 17 patients with chronic active hepatitis, and 29 patients with liver cirrhosis. TBG was significantly above normal levels in both groups of chronic hepatitis, the slight concomitant T4 and T3 increase was significant only for T4 in chronic persistent hepatitis. A significant decrease in T4 and T3 concentration was found in fatty liver disease and in hepatic cirrhosis. A shift in T4 conversion to rT3 could exclusively be demonstrated for the group of hepatic cirrhosis, reflected by a significant increase in rT3. As our findings indicate normal TSH levels and a lack of clinical signs of hypothyroidism in chronic liver disease, the possibility of diverse regulating changes must be considered. SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/6162877/Relations_between_serum_levels_of_TSH_TBG_T4_T3_rT3_and_various_histologically_classified_chronic_liver_diseases_ L2 - https://link.springer.com/article/10.1007/bf03349374 DB - PRIME DP - Unbound Medicine ER -