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Management of depression with serotonin precursors.
Biol Psychiatry 1981; 16(3):291-310BP

Abstract

5-HT precursors are used in depressions on the basis of the 5-HT hypothesis--a hypothesis which postulates that a cerebral 5-HT deficiency can play a role in the pathogenesis of depressions. This article presents a survey of the results obtained by this therapeutic strategy. There are strong indications that 5-HTP is of therapeutic value, particularly in the 5-HT-deficient subgroup of vital depressions. In the same subgroup, one controlled study has so far also shown a prophylatic 5-HTP effect. The results of tryptophan studies are less unequivocal, possibly due to pharmacokinetic factors. Another possible explanation might be that, unlike 5-HTP research, tryptophan studies have so far disregarded the patient's serotonergic status. 5-HT research in depressions has also yielded the concept of the biochemical classifiability of depressions. This may become an important supplement to the conventional criteria of classification of depressions: symptomatology, etiology, and course.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6164407

Citation

van Praag, H M.. "Management of Depression With Serotonin Precursors." Biological Psychiatry, vol. 16, no. 3, 1981, pp. 291-310.
van Praag HM. Management of depression with serotonin precursors. Biol Psychiatry. 1981;16(3):291-310.
van Praag, H. M. (1981). Management of depression with serotonin precursors. Biological Psychiatry, 16(3), pp. 291-310.
van Praag HM. Management of Depression With Serotonin Precursors. Biol Psychiatry. 1981;16(3):291-310. PubMed PMID: 6164407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Management of depression with serotonin precursors. A1 - van Praag,H M, PY - 1981/3/1/pubmed PY - 1981/3/1/medline PY - 1981/3/1/entrez SP - 291 EP - 310 JF - Biological psychiatry JO - Biol. Psychiatry VL - 16 IS - 3 N2 - 5-HT precursors are used in depressions on the basis of the 5-HT hypothesis--a hypothesis which postulates that a cerebral 5-HT deficiency can play a role in the pathogenesis of depressions. This article presents a survey of the results obtained by this therapeutic strategy. There are strong indications that 5-HTP is of therapeutic value, particularly in the 5-HT-deficient subgroup of vital depressions. In the same subgroup, one controlled study has so far also shown a prophylatic 5-HTP effect. The results of tryptophan studies are less unequivocal, possibly due to pharmacokinetic factors. Another possible explanation might be that, unlike 5-HTP research, tryptophan studies have so far disregarded the patient's serotonergic status. 5-HT research in depressions has also yielded the concept of the biochemical classifiability of depressions. This may become an important supplement to the conventional criteria of classification of depressions: symptomatology, etiology, and course. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/6164407/Management_of_depression_with_serotonin_precursors_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -