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Immunological response of subacute sclerosing panencephalitis patients to measles virus.
Neurol Neurocir Psiquiatr. 1977; 18(2-3 Suppl):509-20.NN

Abstract

The immunological responses of patients with clinical signs of SSPE were examined by the direct migration inhibition, complement-mediated antibody cytoxicity and the lymphocyte-mediated cytotoxicity assay techniques. Peripheral lymphocytes migrated similarly to controls when exposed to measles antigen. Lymphocytes from SSPE patients responded to a SSPE strain of measles infected cells in a manner similar to lymphocytes from controls. A factor which interfered with the expected activity of sensitized lymphocytes to measles virus was detected in some cerebral spinal fluid obtained from SSPE patients. The blocking activity varied from 100% in 4 of 20 patients with SSPE to no blocking in 2 of the SSPE patients. The occurrence of blocking factor in SSPE patients could not be related to sex or age of the patient, serum of CSF antibody levels, and duration of disease or outcome.

Authors

Madden DL
No affiliation info available
Fuccillo DA
No affiliation info available
Castellano G
No affiliation info available
Traub R
No affiliation info available
Krezlewicz A
No affiliation info available
Sever JL
No affiliation info available

MeSH

Antibodies, ViralCell Migration InhibitionCerebrospinal FluidComplement System ProteinsCytotoxicity, ImmunologicFemaleHumansImmunityLeukocytesLymphocytesMaleMeaslesMeasles virusSubacute Sclerosing Panencephalitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

616551

Citation

Madden, D L., et al. "Immunological Response of Subacute Sclerosing Panencephalitis Patients to Measles Virus." Neurologia, Neurocirugia, Psiquiatria, vol. 18, no. 2-3 Suppl, 1977, pp. 509-20.
Madden DL, Fuccillo DA, Castellano G, et al. Immunological response of subacute sclerosing panencephalitis patients to measles virus. Neurol Neurocir Psiquiatr. 1977;18(2-3 Suppl):509-20.
Madden, D. L., Fuccillo, D. A., Castellano, G., Traub, R., Krezlewicz, A., & Sever, J. L. (1977). Immunological response of subacute sclerosing panencephalitis patients to measles virus. Neurologia, Neurocirugia, Psiquiatria, 18(2-3 Suppl), 509-20.
Madden DL, et al. Immunological Response of Subacute Sclerosing Panencephalitis Patients to Measles Virus. Neurol Neurocir Psiquiatr. 1977;18(2-3 Suppl):509-20. PubMed PMID: 616551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunological response of subacute sclerosing panencephalitis patients to measles virus. AU - Madden,D L, AU - Fuccillo,D A, AU - Castellano,G, AU - Traub,R, AU - Krezlewicz,A, AU - Sever,J L, PY - 1977/1/1/pubmed PY - 1977/1/1/medline PY - 1977/1/1/entrez SP - 509 EP - 20 JF - Neurologia, neurocirugia, psiquiatria JO - Neurol Neurocir Psiquiatr VL - 18 IS - 2-3 Suppl N2 - The immunological responses of patients with clinical signs of SSPE were examined by the direct migration inhibition, complement-mediated antibody cytoxicity and the lymphocyte-mediated cytotoxicity assay techniques. Peripheral lymphocytes migrated similarly to controls when exposed to measles antigen. Lymphocytes from SSPE patients responded to a SSPE strain of measles infected cells in a manner similar to lymphocytes from controls. A factor which interfered with the expected activity of sensitized lymphocytes to measles virus was detected in some cerebral spinal fluid obtained from SSPE patients. The blocking activity varied from 100% in 4 of 20 patients with SSPE to no blocking in 2 of the SSPE patients. The occurrence of blocking factor in SSPE patients could not be related to sex or age of the patient, serum of CSF antibody levels, and duration of disease or outcome. SN - 0028-3851 UR - https://www.unboundmedicine.com/medline/citation/616551/Immunological_response_of_subacute_sclerosing_panencephalitis_patients_to_measles_virus_ L2 - https://www.diseaseinfosearch.org/result/6907 DB - PRIME DP - Unbound Medicine ER -