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Experimental allergic encephalomyelitis in Lewis rats: inhibition by bacterial lipopolysaccharides and acquired resistance to reinduction by challenge with myelin basic protein.
J Immunol. 1981 Jul; 127(1):16-20.JI

Abstract

In 2-mo-old Lewis rats immunized with bacterial lipopolysaccharides (LPS) precomplexed to guinea pig myelin basic protein (BP), the clinical and histologic manifestations of experimental allergic encephalomyelitis (EAE) were diminished compared with BP-treated controls. Similarly, in animals immunized with BP and challenged with BP-LPS at the same time or as long as 5 days after, the immunization with BP also inhibited the disease. That this capacity to reduce the incidence of BP-induced EAE is a unique property of LPS was suggested by the fact that other negatively charged molecules, such as DNA, RNA, and dextran sulphate, were not effective in inhibiting the clinical signs of EAE. After recovery from EAE induced by BP, some animals develop a recurrence of the disease if challenged with BP at appropriate intervals. However, after recovery from mild EAE induced by BP-LPS and after challenges with EAE-initiating BP antigens, secondary EAE was inhibited significantly.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6165759

Citation

Raziuddin, S, et al. "Experimental Allergic Encephalomyelitis in Lewis Rats: Inhibition By Bacterial Lipopolysaccharides and Acquired Resistance to Reinduction By Challenge With Myelin Basic Protein." Journal of Immunology (Baltimore, Md. : 1950), vol. 127, no. 1, 1981, pp. 16-20.
Raziuddin S, Kibler RF, Morrison DC. Experimental allergic encephalomyelitis in Lewis rats: inhibition by bacterial lipopolysaccharides and acquired resistance to reinduction by challenge with myelin basic protein. J Immunol. 1981;127(1):16-20.
Raziuddin, S., Kibler, R. F., & Morrison, D. C. (1981). Experimental allergic encephalomyelitis in Lewis rats: inhibition by bacterial lipopolysaccharides and acquired resistance to reinduction by challenge with myelin basic protein. Journal of Immunology (Baltimore, Md. : 1950), 127(1), 16-20.
Raziuddin S, Kibler RF, Morrison DC. Experimental Allergic Encephalomyelitis in Lewis Rats: Inhibition By Bacterial Lipopolysaccharides and Acquired Resistance to Reinduction By Challenge With Myelin Basic Protein. J Immunol. 1981;127(1):16-20. PubMed PMID: 6165759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental allergic encephalomyelitis in Lewis rats: inhibition by bacterial lipopolysaccharides and acquired resistance to reinduction by challenge with myelin basic protein. AU - Raziuddin,S, AU - Kibler,R F, AU - Morrison,D C, PY - 1981/7/1/pubmed PY - 1981/7/1/medline PY - 1981/7/1/entrez SP - 16 EP - 20 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 127 IS - 1 N2 - In 2-mo-old Lewis rats immunized with bacterial lipopolysaccharides (LPS) precomplexed to guinea pig myelin basic protein (BP), the clinical and histologic manifestations of experimental allergic encephalomyelitis (EAE) were diminished compared with BP-treated controls. Similarly, in animals immunized with BP and challenged with BP-LPS at the same time or as long as 5 days after, the immunization with BP also inhibited the disease. That this capacity to reduce the incidence of BP-induced EAE is a unique property of LPS was suggested by the fact that other negatively charged molecules, such as DNA, RNA, and dextran sulphate, were not effective in inhibiting the clinical signs of EAE. After recovery from EAE induced by BP, some animals develop a recurrence of the disease if challenged with BP at appropriate intervals. However, after recovery from mild EAE induced by BP-LPS and after challenges with EAE-initiating BP antigens, secondary EAE was inhibited significantly. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/6165759/Experimental_allergic_encephalomyelitis_in_Lewis_rats:_inhibition_by_bacterial_lipopolysaccharides_and_acquired_resistance_to_reinduction_by_challenge_with_myelin_basic_protein_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=6165759 DB - PRIME DP - Unbound Medicine ER -