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Effect of xylometazoline nasal spray on nasal conductance in subjects with coryza.
J Otolaryngol 1981; 10(2):109-16JO

Abstract

The ability of xylometazoline topical spray to reduce nasal congestion was evaluated in 44 normal subjects with coryza due to upper respiratory infection. Rating scales were completed for the subjective response and nasal airway resistance (expressed as nasal conductance, Gn) measured for the objective response over six hours. In 30 subjects, post treatment Gn was compared to the measurement after their colds had subsided. The increase in Gn following xylometazoline was rapid and profound, remaining significantly elevated for the six hour period, and it was greater than the asymptomatic value from 10 minutes to nearly five hours. Other symptoms were not markedly affected by the medication. Subjective scores indicated continued relief after treatment, but the small negative correlation suggested that rating scales were not reliable indices of nasal congestion. No differences were observed in the responses when cigarette smokers were compared with nonsmokers.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

6165826

Citation

Hamilton, L H.. "Effect of Xylometazoline Nasal Spray On Nasal Conductance in Subjects With Coryza." The Journal of Otolaryngology, vol. 10, no. 2, 1981, pp. 109-16.
Hamilton LH. Effect of xylometazoline nasal spray on nasal conductance in subjects with coryza. J Otolaryngol. 1981;10(2):109-16.
Hamilton, L. H. (1981). Effect of xylometazoline nasal spray on nasal conductance in subjects with coryza. The Journal of Otolaryngology, 10(2), pp. 109-16.
Hamilton LH. Effect of Xylometazoline Nasal Spray On Nasal Conductance in Subjects With Coryza. J Otolaryngol. 1981;10(2):109-16. PubMed PMID: 6165826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of xylometazoline nasal spray on nasal conductance in subjects with coryza. A1 - Hamilton,L H, PY - 1981/4/1/pubmed PY - 1981/4/1/medline PY - 1981/4/1/entrez SP - 109 EP - 16 JF - The Journal of otolaryngology JO - J Otolaryngol VL - 10 IS - 2 N2 - The ability of xylometazoline topical spray to reduce nasal congestion was evaluated in 44 normal subjects with coryza due to upper respiratory infection. Rating scales were completed for the subjective response and nasal airway resistance (expressed as nasal conductance, Gn) measured for the objective response over six hours. In 30 subjects, post treatment Gn was compared to the measurement after their colds had subsided. The increase in Gn following xylometazoline was rapid and profound, remaining significantly elevated for the six hour period, and it was greater than the asymptomatic value from 10 minutes to nearly five hours. Other symptoms were not markedly affected by the medication. Subjective scores indicated continued relief after treatment, but the small negative correlation suggested that rating scales were not reliable indices of nasal congestion. No differences were observed in the responses when cigarette smokers were compared with nonsmokers. SN - 0381-6605 UR - https://www.unboundmedicine.com/medline/citation/6165826/Effect_of_xylometazoline_nasal_spray_on_nasal_conductance_in_subjects_with_coryza_ L2 - https://medlineplus.gov/coldandcoughmedicines.html DB - PRIME DP - Unbound Medicine ER -