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Anaphylactic histamine release from peritoneal mast cells of two inbred strains of rats sensitized with mouse IgE.
Agents Actions. 1981 Apr; 11(1-2):100-2.AA

Abstract

Peritoneal mast cells from rats of BH- and DA-inbred strains were compared for their capacity to passive sensitization in vitro with mouse IgE antibodies. In identical experimental conditions mast cells of BH-rats were good receptors for mouse IgE anti-KLH fraction and released histamine when challenged with specific antigen, whereas mast cells of DA-rats were much less sensitized and released little histamine on the challenge. In contrast, mast cells of DA-rats wee more susceptible to the challenge with anti-rat IgE and Concanavalin A, than were cells of BH-rats. This susceptibility correlated with total serum IgE level, which was higher in DA- than in BH-rats. These results show higher concentrations of IgE on mast cells of DA--rats. It is suggested that rat IgE present on normal mast cells may be one of the factors interfering in in vitro sensitization of the cells from DA-rats with mouse IgE antibodies.

Authors

Wyczótkowska J
No affiliation info available
Brzezińska-Błaszczyk E
No affiliation info available
Maśliński C
No affiliation info available

MeSH

AnaphylaxisAnimalsAscitic FluidConcanavalin AFemaleHistamine ReleaseImmunoglobulin EMast CellsMiceRatsRats, Inbred Strains

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6166159

Citation

Wyczótkowska, J, et al. "Anaphylactic Histamine Release From Peritoneal Mast Cells of Two Inbred Strains of Rats Sensitized With Mouse IgE." Agents and Actions, vol. 11, no. 1-2, 1981, pp. 100-2.
Wyczótkowska J, Brzezińska-Błaszczyk E, Maśliński C. Anaphylactic histamine release from peritoneal mast cells of two inbred strains of rats sensitized with mouse IgE. Agents Actions. 1981;11(1-2):100-2.
Wyczótkowska, J., Brzezińska-Błaszczyk, E., & Maśliński, C. (1981). Anaphylactic histamine release from peritoneal mast cells of two inbred strains of rats sensitized with mouse IgE. Agents and Actions, 11(1-2), 100-2.
Wyczótkowska J, Brzezińska-Błaszczyk E, Maśliński C. Anaphylactic Histamine Release From Peritoneal Mast Cells of Two Inbred Strains of Rats Sensitized With Mouse IgE. Agents Actions. 1981;11(1-2):100-2. PubMed PMID: 6166159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anaphylactic histamine release from peritoneal mast cells of two inbred strains of rats sensitized with mouse IgE. AU - Wyczótkowska,J, AU - Brzezińska-Błaszczyk,E, AU - Maśliński,C, PY - 1981/4/1/pubmed PY - 1981/4/1/medline PY - 1981/4/1/entrez SP - 100 EP - 2 JF - Agents and actions JO - Agents Actions VL - 11 IS - 1-2 N2 - Peritoneal mast cells from rats of BH- and DA-inbred strains were compared for their capacity to passive sensitization in vitro with mouse IgE antibodies. In identical experimental conditions mast cells of BH-rats were good receptors for mouse IgE anti-KLH fraction and released histamine when challenged with specific antigen, whereas mast cells of DA-rats were much less sensitized and released little histamine on the challenge. In contrast, mast cells of DA-rats wee more susceptible to the challenge with anti-rat IgE and Concanavalin A, than were cells of BH-rats. This susceptibility correlated with total serum IgE level, which was higher in DA- than in BH-rats. These results show higher concentrations of IgE on mast cells of DA--rats. It is suggested that rat IgE present on normal mast cells may be one of the factors interfering in in vitro sensitization of the cells from DA-rats with mouse IgE antibodies. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/6166159/Anaphylactic_histamine_release_from_peritoneal_mast_cells_of_two_inbred_strains_of_rats_sensitized_with_mouse_IgE_ L2 - https://medlineplus.gov/anaphylaxis.html DB - PRIME DP - Unbound Medicine ER -