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A modulation of the anaphylactic basophil histamine release by selective H2 histamine agonists.
Agents Actions. 1981 Apr; 11(1-2):96-8.AA

Abstract

Two selective H2-histamine agonists, dimaprit and impromidine, have been tested for their action on histamine release from human basophils and rat mast cells. IgE-mediated basophil histamine release was inhibited by stimulation of histamine H2-receptors. However, differences between the actions of both dimaprit and impromidine were noticed. Both impromidine and dimaprit had no specific effect on 48/80-induced histamine release from rat mast cells, although the latter in higher concentrations either slightly increased spontaneous histamine release or non-specifically inhibited compound 48/80-induced release. The results are consistent with the view that activation of adenylate cyclase via H2-histamine receptors might be an important regulatory mechanism of histamine release from human basophils but not from rat mast cells.

Authors

Kazimierczak W
No affiliation info available
Szczepaniak K
No affiliation info available
Bańkowska K
No affiliation info available

MeSH

AllergensAnaphylaxisBasophilsDimapritGuanidinesHistamine ReleaseHumansImidazolesImpromidineIn Vitro TechniquesMast CellsReceptors, HistamineReceptors, Histamine H2Thioureap-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6166177

Citation

Kazimierczak, W, et al. "A Modulation of the Anaphylactic Basophil Histamine Release By Selective H2 Histamine Agonists." Agents and Actions, vol. 11, no. 1-2, 1981, pp. 96-8.
Kazimierczak W, Szczepaniak K, Bańkowska K. A modulation of the anaphylactic basophil histamine release by selective H2 histamine agonists. Agents Actions. 1981;11(1-2):96-8.
Kazimierczak, W., Szczepaniak, K., & Bańkowska, K. (1981). A modulation of the anaphylactic basophil histamine release by selective H2 histamine agonists. Agents and Actions, 11(1-2), 96-8.
Kazimierczak W, Szczepaniak K, Bańkowska K. A Modulation of the Anaphylactic Basophil Histamine Release By Selective H2 Histamine Agonists. Agents Actions. 1981;11(1-2):96-8. PubMed PMID: 6166177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A modulation of the anaphylactic basophil histamine release by selective H2 histamine agonists. AU - Kazimierczak,W, AU - Szczepaniak,K, AU - Bańkowska,K, PY - 1981/4/1/pubmed PY - 1981/4/1/medline PY - 1981/4/1/entrez SP - 96 EP - 8 JF - Agents and actions JO - Agents Actions VL - 11 IS - 1-2 N2 - Two selective H2-histamine agonists, dimaprit and impromidine, have been tested for their action on histamine release from human basophils and rat mast cells. IgE-mediated basophil histamine release was inhibited by stimulation of histamine H2-receptors. However, differences between the actions of both dimaprit and impromidine were noticed. Both impromidine and dimaprit had no specific effect on 48/80-induced histamine release from rat mast cells, although the latter in higher concentrations either slightly increased spontaneous histamine release or non-specifically inhibited compound 48/80-induced release. The results are consistent with the view that activation of adenylate cyclase via H2-histamine receptors might be an important regulatory mechanism of histamine release from human basophils but not from rat mast cells. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/6166177/A_modulation_of_the_anaphylactic_basophil_histamine_release_by_selective_H2_histamine_agonists_ L2 - https://medlineplus.gov/anaphylaxis.html DB - PRIME DP - Unbound Medicine ER -