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Regulation of experimental allergic encephalomyelitis. III. Demonstration of effector cells in tolerant rats.
Eur J Immunol. 1981 Apr; 11(4):338-40.EJ

Abstract

Effector cells, which transfer experimental allergic encephalomyelitis (EAE), can be demonstrated in the spleens of Lewis rats which have been rendered tolerant to myelin basic protein (BP). Transfer of EAE was achieved following in vitro culture of tolerant donor spleen cells with antigen. The donor animals were, themselves, protected against EAE induced by active challenge with BP in complete Freund's adjuvant, although BP-activated effector spleen cells could partially override this protection. The finding that effector cells are present in unresponsive animals supports the hypothesis that immunologic self tolerance is actively regulated by suppressor mechanisms.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6166483

Citation

Holda, J H., and R H. Swanborg. "Regulation of Experimental Allergic Encephalomyelitis. III. Demonstration of Effector Cells in Tolerant Rats." European Journal of Immunology, vol. 11, no. 4, 1981, pp. 338-40.
Holda JH, Swanborg RH. Regulation of experimental allergic encephalomyelitis. III. Demonstration of effector cells in tolerant rats. Eur J Immunol. 1981;11(4):338-40.
Holda, J. H., & Swanborg, R. H. (1981). Regulation of experimental allergic encephalomyelitis. III. Demonstration of effector cells in tolerant rats. European Journal of Immunology, 11(4), 338-40.
Holda JH, Swanborg RH. Regulation of Experimental Allergic Encephalomyelitis. III. Demonstration of Effector Cells in Tolerant Rats. Eur J Immunol. 1981;11(4):338-40. PubMed PMID: 6166483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of experimental allergic encephalomyelitis. III. Demonstration of effector cells in tolerant rats. AU - Holda,J H, AU - Swanborg,R H, PY - 1981/4/1/pubmed PY - 1981/4/1/medline PY - 1981/4/1/entrez SP - 338 EP - 40 JF - European journal of immunology JO - Eur J Immunol VL - 11 IS - 4 N2 - Effector cells, which transfer experimental allergic encephalomyelitis (EAE), can be demonstrated in the spleens of Lewis rats which have been rendered tolerant to myelin basic protein (BP). Transfer of EAE was achieved following in vitro culture of tolerant donor spleen cells with antigen. The donor animals were, themselves, protected against EAE induced by active challenge with BP in complete Freund's adjuvant, although BP-activated effector spleen cells could partially override this protection. The finding that effector cells are present in unresponsive animals supports the hypothesis that immunologic self tolerance is actively regulated by suppressor mechanisms. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/6166483/Regulation_of_experimental_allergic_encephalomyelitis__III__Demonstration_of_effector_cells_in_tolerant_rats_ L2 - https://doi.org/10.1002/eji.1830110414 DB - PRIME DP - Unbound Medicine ER -