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Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells.
Agents Actions. 1981 May; 11(3):184-92.AA

Abstract

Oxatomide inhibits the release of histamine from rat peritoneal mast cells in vitro induced by C 48/80, antigen, anti-IgE and ionophore A 23 187, without effect on non-specific release by n-decylamine. Its effect is concentration- and pH-dependent and decreases with increasing extracellular Ca2+-concentrations. Prolonged incubation does not enhance the inhibition, which is lost after one single wash-out. Aminophylline and isoproterenol are not potentiated by oxatomide. The present study points to an effect of oxatomide on a Ca2+-dependent process at the level of cell membrane common to antigen, C 48/80 and ionophore A 23 187.

Authors

De Clerck F
No affiliation info available
Van Reempts J
No affiliation info available
Borgers M
No affiliation info available

MeSH

AnimalsAntibodies, Anti-IdiotypicAntigensAscitic FluidCalcimycinCalciumHistamine ReleaseImmunoglobulin EIn Vitro TechniquesMaleMast CellsPiperazinesRatsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6167156

Citation

De Clerck, F, et al. "Comparative Effects of Oxatomide On the Release of Histamine From Rat Peritoneal Mast Cells." Agents and Actions, vol. 11, no. 3, 1981, pp. 184-92.
De Clerck F, Van Reempts J, Borgers M. Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells. Agents Actions. 1981;11(3):184-92.
De Clerck, F., Van Reempts, J., & Borgers, M. (1981). Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells. Agents and Actions, 11(3), 184-92.
De Clerck F, Van Reempts J, Borgers M. Comparative Effects of Oxatomide On the Release of Histamine From Rat Peritoneal Mast Cells. Agents Actions. 1981;11(3):184-92. PubMed PMID: 6167156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative effects of oxatomide on the release of histamine from rat peritoneal mast cells. AU - De Clerck,F, AU - Van Reempts,J, AU - Borgers,M, PY - 1981/5/1/pubmed PY - 1981/5/1/medline PY - 1981/5/1/entrez SP - 184 EP - 92 JF - Agents and actions JO - Agents Actions VL - 11 IS - 3 N2 - Oxatomide inhibits the release of histamine from rat peritoneal mast cells in vitro induced by C 48/80, antigen, anti-IgE and ionophore A 23 187, without effect on non-specific release by n-decylamine. Its effect is concentration- and pH-dependent and decreases with increasing extracellular Ca2+-concentrations. Prolonged incubation does not enhance the inhibition, which is lost after one single wash-out. Aminophylline and isoproterenol are not potentiated by oxatomide. The present study points to an effect of oxatomide on a Ca2+-dependent process at the level of cell membrane common to antigen, C 48/80 and ionophore A 23 187. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/6167156/Comparative_effects_of_oxatomide_on_the_release_of_histamine_from_rat_peritoneal_mast_cells_ DB - PRIME DP - Unbound Medicine ER -