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Effect of anti-allergic compounds on histamine release from rat peritoneal mast cells treated with concanavalin A.
Int Arch Allergy Appl Immunol. 1981; 66(1):76-82.IA

Abstract

The anti-allergic drugs theophylline, doxantrazole, quercetin, dibutyryl cyclic AMP, and disodium cromoglycate prevented histamine release induced by concanavalin A in both the presence and absence of extracellular calcium. The compounds were generally most effective in the absence of added calcium and least effective in the simultaneous presence of calcium and phosphatidyl serine. The activity of the test drugs in calcium-free media clearly cannot be explained in terms of their postulated ability to block movement of the ion from the external environment into the cell. Alternative modes of action are thus considered.

Authors

Truneh A
No affiliation info available
Pearce FL
No affiliation info available

MeSH

AnimalsBucladesineConcanavalin ACromolyn SodiumDose-Response Relationship, DrugEdetic AcidHistamine ReleaseMast CellsPhosphatidylserinesQuercetinRatsTetrazolesTheophyllineThioxanthenesXanthones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6167528

Citation

Truneh, A, and F L. Pearce. "Effect of Anti-allergic Compounds On Histamine Release From Rat Peritoneal Mast Cells Treated With Concanavalin A." International Archives of Allergy and Applied Immunology, vol. 66, no. 1, 1981, pp. 76-82.
Truneh A, Pearce FL. Effect of anti-allergic compounds on histamine release from rat peritoneal mast cells treated with concanavalin A. Int Arch Allergy Appl Immunol. 1981;66(1):76-82.
Truneh, A., & Pearce, F. L. (1981). Effect of anti-allergic compounds on histamine release from rat peritoneal mast cells treated with concanavalin A. International Archives of Allergy and Applied Immunology, 66(1), 76-82.
Truneh A, Pearce FL. Effect of Anti-allergic Compounds On Histamine Release From Rat Peritoneal Mast Cells Treated With Concanavalin A. Int Arch Allergy Appl Immunol. 1981;66(1):76-82. PubMed PMID: 6167528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of anti-allergic compounds on histamine release from rat peritoneal mast cells treated with concanavalin A. AU - Truneh,A, AU - Pearce,F L, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 76 EP - 82 JF - International archives of allergy and applied immunology JO - Int Arch Allergy Appl Immunol VL - 66 IS - 1 N2 - The anti-allergic drugs theophylline, doxantrazole, quercetin, dibutyryl cyclic AMP, and disodium cromoglycate prevented histamine release induced by concanavalin A in both the presence and absence of extracellular calcium. The compounds were generally most effective in the absence of added calcium and least effective in the simultaneous presence of calcium and phosphatidyl serine. The activity of the test drugs in calcium-free media clearly cannot be explained in terms of their postulated ability to block movement of the ion from the external environment into the cell. Alternative modes of action are thus considered. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/6167528/Effect_of_anti_allergic_compounds_on_histamine_release_from_rat_peritoneal_mast_cells_treated_with_concanavalin_A_ DB - PRIME DP - Unbound Medicine ER -