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Dependence of anaphylactic histamine release from rat mast cells on cellular energy metabolism.
Eur J Pharmacol. 1981 Jul 10; 72(4):281-6.EJ

Abstract

The relation between anaphylactic histamine release and the adenosine triphosphate (ATP) content of the mast cells was studied. The cells were incubated with glycolytic (2-deoxyglucose) and respiratory inhibitors (antimycin A and oligomycin) in order to decrease the ATP content of the cells prior to initiation of the release process by the antigen-antibody reaction. The secretory capacity of mast cells was less related to the cellular level of ATP at the time of activation of the release process by the antigen-antibody reaction than to the rate of cellular energy supply. Furthermore, mast cells were pretreated with 2-deoxyglucose. The release of histamine from these cells was reduced when respiratory inhibitors were added to the cell suspension 5 to 20 sec after exposure of the cells to antigen. This may indicate that the secretory process requires energy, and it seems necessary that energy should be produced as the release of histamine takes place.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6168473

Citation

Johansen, T. "Dependence of Anaphylactic Histamine Release From Rat Mast Cells On Cellular Energy Metabolism." European Journal of Pharmacology, vol. 72, no. 4, 1981, pp. 281-6.
Johansen T. Dependence of anaphylactic histamine release from rat mast cells on cellular energy metabolism. Eur J Pharmacol. 1981;72(4):281-6.
Johansen, T. (1981). Dependence of anaphylactic histamine release from rat mast cells on cellular energy metabolism. European Journal of Pharmacology, 72(4), 281-6.
Johansen T. Dependence of Anaphylactic Histamine Release From Rat Mast Cells On Cellular Energy Metabolism. Eur J Pharmacol. 1981 Jul 10;72(4):281-6. PubMed PMID: 6168473.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dependence of anaphylactic histamine release from rat mast cells on cellular energy metabolism. A1 - Johansen,T, PY - 1981/7/10/pubmed PY - 1981/7/10/medline PY - 1981/7/10/entrez SP - 281 EP - 6 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 72 IS - 4 N2 - The relation between anaphylactic histamine release and the adenosine triphosphate (ATP) content of the mast cells was studied. The cells were incubated with glycolytic (2-deoxyglucose) and respiratory inhibitors (antimycin A and oligomycin) in order to decrease the ATP content of the cells prior to initiation of the release process by the antigen-antibody reaction. The secretory capacity of mast cells was less related to the cellular level of ATP at the time of activation of the release process by the antigen-antibody reaction than to the rate of cellular energy supply. Furthermore, mast cells were pretreated with 2-deoxyglucose. The release of histamine from these cells was reduced when respiratory inhibitors were added to the cell suspension 5 to 20 sec after exposure of the cells to antigen. This may indicate that the secretory process requires energy, and it seems necessary that energy should be produced as the release of histamine takes place. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/6168473/Dependence_of_anaphylactic_histamine_release_from_rat_mast_cells_on_cellular_energy_metabolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(81)90565-3 DB - PRIME DP - Unbound Medicine ER -