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In vitro studies on the mechanism of action of a new antiallergic, Ro 21-7634.
Agents Actions. 1981 Jul; 11(4):345-51.AA

Abstract

The effects of Ro 21-7634 and disodium cromoglycate (cromoglycate) on the in vitro release of mediators of anaphylaxis from rat peritoneal cells and guinea pig lung tissue were compared. Ro 21-7634 was 25 fold more potent than cromoglycate as an inhibitor of antigen-induced histamine release from passively sensitized (IgE) rat peritoneal cells. Ro 21-7634 was also the more potent inhibitor of both compound 48/80- and concanavalin A-induced histamine release from rat peritoneal cells. The two drugs shared the common properties of producing the same maximal level of inhibition in each of the above releasing systems and exhibiting a time and concentration dependent loss of inhibitory activity when added to the cells prior to the releasing agent. Neither drug inhibited ionophore A23187-or ionophore X537A-induced histamine release from these cells. Ro 21-7634 inhibited antigen-induced (IgG1) histamine and SRS-A release from actively sensitized guinea pig lung fragments, whereas cromoglycate did not. The results indicate that Ro 21-7634 and cromoglycate act through a common mechanism to inhibit allergic mediator release and that Ro 21-7634 is the more potent inhibitor.

Authors

Welton AF
No affiliation info available
Hope WC
No affiliation info available
Crowley HJ
No affiliation info available
Salvador RA
No affiliation info available

MeSH

AnimalsConcanavalin ACromolyn SodiumHistamine AntagonistsHistamine ReleaseLungMaleMast CellsRatsSRS-Ap-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6169263

Citation

Welton, A F., et al. "In Vitro Studies On the Mechanism of Action of a New Antiallergic, Ro 21-7634." Agents and Actions, vol. 11, no. 4, 1981, pp. 345-51.
Welton AF, Hope WC, Crowley HJ, et al. In vitro studies on the mechanism of action of a new antiallergic, Ro 21-7634. Agents Actions. 1981;11(4):345-51.
Welton, A. F., Hope, W. C., Crowley, H. J., & Salvador, R. A. (1981). In vitro studies on the mechanism of action of a new antiallergic, Ro 21-7634. Agents and Actions, 11(4), 345-51.
Welton AF, et al. In Vitro Studies On the Mechanism of Action of a New Antiallergic, Ro 21-7634. Agents Actions. 1981;11(4):345-51. PubMed PMID: 6169263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro studies on the mechanism of action of a new antiallergic, Ro 21-7634. AU - Welton,A F, AU - Hope,W C, AU - Crowley,H J, AU - Salvador,R A, PY - 1981/7/1/pubmed PY - 1981/7/1/medline PY - 1981/7/1/entrez SP - 345 EP - 51 JF - Agents and actions JO - Agents Actions VL - 11 IS - 4 N2 - The effects of Ro 21-7634 and disodium cromoglycate (cromoglycate) on the in vitro release of mediators of anaphylaxis from rat peritoneal cells and guinea pig lung tissue were compared. Ro 21-7634 was 25 fold more potent than cromoglycate as an inhibitor of antigen-induced histamine release from passively sensitized (IgE) rat peritoneal cells. Ro 21-7634 was also the more potent inhibitor of both compound 48/80- and concanavalin A-induced histamine release from rat peritoneal cells. The two drugs shared the common properties of producing the same maximal level of inhibition in each of the above releasing systems and exhibiting a time and concentration dependent loss of inhibitory activity when added to the cells prior to the releasing agent. Neither drug inhibited ionophore A23187-or ionophore X537A-induced histamine release from these cells. Ro 21-7634 inhibited antigen-induced (IgG1) histamine and SRS-A release from actively sensitized guinea pig lung fragments, whereas cromoglycate did not. The results indicate that Ro 21-7634 and cromoglycate act through a common mechanism to inhibit allergic mediator release and that Ro 21-7634 is the more potent inhibitor. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/6169263/In_vitro_studies_on_the_mechanism_of_action_of_a_new_antiallergic_Ro_21_7634_ L2 - https://medlineplus.gov/coldandcoughmedicines.html DB - PRIME DP - Unbound Medicine ER -