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Suppression of experimental allergic encephalomyelitis by transfer of lymph node cells from Lewis rats pretreated with complete Freund's adjuvant.
Int Arch Allergy Appl Immunol. 1981; 66(3):326-31.IA

Abstract

Experimental allergic encephalomyelitis (EAE) in Lewis rats was suppressed by pretreatment with complete Freund's adjuvant (CFA) 14-16 days before immunization with basic protein (BP) in CFA. Suppression of active EAE was also accomplished clinically and even histologically if lymph node cells from CFA-treated donors were passively transferred. Obviously this depends first on a certain amount of transferred lymph node cells (about 3 X 108) and secondly on the interval between CFA application and cell harvest (more than 14 days). No suppression was obtained by transfer of serum from CFA-treated donors. This indicates that there is a suppressor cell population which can be raised or stimulated by CFA and which is capable of suppressing the immune response EAE.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6170593

Citation

Englert, D, and K Hempel. "Suppression of Experimental Allergic Encephalomyelitis By Transfer of Lymph Node Cells From Lewis Rats Pretreated With Complete Freund's Adjuvant." International Archives of Allergy and Applied Immunology, vol. 66, no. 3, 1981, pp. 326-31.
Englert D, Hempel K. Suppression of experimental allergic encephalomyelitis by transfer of lymph node cells from Lewis rats pretreated with complete Freund's adjuvant. Int Arch Allergy Appl Immunol. 1981;66(3):326-31.
Englert, D., & Hempel, K. (1981). Suppression of experimental allergic encephalomyelitis by transfer of lymph node cells from Lewis rats pretreated with complete Freund's adjuvant. International Archives of Allergy and Applied Immunology, 66(3), 326-31.
Englert D, Hempel K. Suppression of Experimental Allergic Encephalomyelitis By Transfer of Lymph Node Cells From Lewis Rats Pretreated With Complete Freund's Adjuvant. Int Arch Allergy Appl Immunol. 1981;66(3):326-31. PubMed PMID: 6170593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of experimental allergic encephalomyelitis by transfer of lymph node cells from Lewis rats pretreated with complete Freund's adjuvant. AU - Englert,D, AU - Hempel,K, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 326 EP - 31 JF - International archives of allergy and applied immunology JO - Int Arch Allergy Appl Immunol VL - 66 IS - 3 N2 - Experimental allergic encephalomyelitis (EAE) in Lewis rats was suppressed by pretreatment with complete Freund's adjuvant (CFA) 14-16 days before immunization with basic protein (BP) in CFA. Suppression of active EAE was also accomplished clinically and even histologically if lymph node cells from CFA-treated donors were passively transferred. Obviously this depends first on a certain amount of transferred lymph node cells (about 3 X 108) and secondly on the interval between CFA application and cell harvest (more than 14 days). No suppression was obtained by transfer of serum from CFA-treated donors. This indicates that there is a suppressor cell population which can be raised or stimulated by CFA and which is capable of suppressing the immune response EAE. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/6170593/Suppression_of_experimental_allergic_encephalomyelitis_by_transfer_of_lymph_node_cells_from_Lewis_rats_pretreated_with_complete_Freund's_adjuvant_ DB - PRIME DP - Unbound Medicine ER -