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Experimental allergic encephalomyelitis induced by basic protein with synthetic adjuvant in comparison with Freund's complete adjuvant. Role of antibodies in correlation with the clinicopathological features.
J Neurol Sci. 1981 Oct; 52(1):133-45.JN

Abstract

Experimental allergic encephalomyelitis (EAE) was induced in guinea pigs with bovine myelin basic protein (BP) with adjuvant of either synthetic muramyl dipeptide (Mdp) or Mycobacterium tuberculosis (Tbc). The following results were obtained: (1) The body temperature of the animals was studied serially after sensitization and its elevation was shown to be an early sign of EAE. (2) Several animals developed the clinical and histological signs of hyperacute EAE. (3) An optimal combined dosage of BP and adjuvant was found for induction of clinical EAE and for the the production of complement fixing (CF) antibodies. (4) Little passive hemagglutinating (PH) antibody was produced by single immunization. These results displayed no essential difference in EAE induced by either adjuvant. (5) Detectable PH antibodies developed later in addition to CF antibodies in a few animals immunized with Tbc adjuvant. These animals were skin-tested to BP, and had recovered from body weight loss or limb weakness. The results suggest that humoral antibodies play a role in modifying the disease process, even if they are not essential in production of EAE.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6170738

Citation

Mitsuzawa, E, et al. "Experimental Allergic Encephalomyelitis Induced By Basic Protein With Synthetic Adjuvant in Comparison With Freund's Complete Adjuvant. Role of Antibodies in Correlation With the Clinicopathological Features." Journal of the Neurological Sciences, vol. 52, no. 1, 1981, pp. 133-45.
Mitsuzawa E, Yasuda T, Tamura N, et al. Experimental allergic encephalomyelitis induced by basic protein with synthetic adjuvant in comparison with Freund's complete adjuvant. Role of antibodies in correlation with the clinicopathological features. J Neurol Sci. 1981;52(1):133-45.
Mitsuzawa, E., Yasuda, T., Tamura, N., & Ohtani, S. (1981). Experimental allergic encephalomyelitis induced by basic protein with synthetic adjuvant in comparison with Freund's complete adjuvant. Role of antibodies in correlation with the clinicopathological features. Journal of the Neurological Sciences, 52(1), 133-45.
Mitsuzawa E, et al. Experimental Allergic Encephalomyelitis Induced By Basic Protein With Synthetic Adjuvant in Comparison With Freund's Complete Adjuvant. Role of Antibodies in Correlation With the Clinicopathological Features. J Neurol Sci. 1981;52(1):133-45. PubMed PMID: 6170738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental allergic encephalomyelitis induced by basic protein with synthetic adjuvant in comparison with Freund's complete adjuvant. Role of antibodies in correlation with the clinicopathological features. AU - Mitsuzawa,E, AU - Yasuda,T, AU - Tamura,N, AU - Ohtani,S, PY - 1981/10/1/pubmed PY - 1981/10/1/medline PY - 1981/10/1/entrez SP - 133 EP - 45 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 52 IS - 1 N2 - Experimental allergic encephalomyelitis (EAE) was induced in guinea pigs with bovine myelin basic protein (BP) with adjuvant of either synthetic muramyl dipeptide (Mdp) or Mycobacterium tuberculosis (Tbc). The following results were obtained: (1) The body temperature of the animals was studied serially after sensitization and its elevation was shown to be an early sign of EAE. (2) Several animals developed the clinical and histological signs of hyperacute EAE. (3) An optimal combined dosage of BP and adjuvant was found for induction of clinical EAE and for the the production of complement fixing (CF) antibodies. (4) Little passive hemagglutinating (PH) antibody was produced by single immunization. These results displayed no essential difference in EAE induced by either adjuvant. (5) Detectable PH antibodies developed later in addition to CF antibodies in a few animals immunized with Tbc adjuvant. These animals were skin-tested to BP, and had recovered from body weight loss or limb weakness. The results suggest that humoral antibodies play a role in modifying the disease process, even if they are not essential in production of EAE. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/6170738/Experimental_allergic_encephalomyelitis_induced_by_basic_protein_with_synthetic_adjuvant_in_comparison_with_Freund's_complete_adjuvant__Role_of_antibodies_in_correlation_with_the_clinicopathological_features_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0022-510X(81)90141-6 DB - PRIME DP - Unbound Medicine ER -