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Suppression of acute experimental allergic encephalomyelitis in guinea pigs by prior transfer of suboptimal numbers of EAE-effector cells: induction of chronic EAE in whole tissue-sensitized guinea pigs.
J Immunol. 1982 Feb; 128(2):635-8.JI

Abstract

Experimental allergic encephalomyelitis (EAE) in strain 13 guinea pigs is an acute monophasic disease induced with myelin basic protein (BP) in complete Freund's adjuvant (CFA). We report here that EAE can be effectively suppressed by transfer of a limited number of EAE-effector cells. Lymph node cells (LNC) from donors sensitized with BP/CFA are activated in vitro by incubation with BP and strain 2 peritoneal exudate cells (PEC). 5 X 10(7) of these cells are capable of inducing lethal EAE in recipients; 0.5 to 1 X 10(7) cells (a suboptimal transfer) effectively suppress EAE induction in animals subsequently sensitized with BP/CFA. Suppressed recipients develop an early mild disease from which they recover completely. In contrast, suboptimal transfer of BP-sensitized cells does not protect recipients against sensitization with whole central nervous system (CNS) tissue/CFA. About 50% of these recipients succumb to acute EAE; the survivors develop chronic EAE of varying intensity: a mild chronic form with recovery, a severe chronic form that is eventually fatal, and a chronic relapsing form that results in permanent neurologic deficit. Preliminary attempts at detecting suppressor cells in the suppressed animals were unsuccessful. Instead, PEC of all recipients of suboptimal transfers were capable of transferring EAE to naive animals.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6172501

Citation

Driscoll, B F., et al. "Suppression of Acute Experimental Allergic Encephalomyelitis in Guinea Pigs By Prior Transfer of Suboptimal Numbers of EAE-effector Cells: Induction of Chronic EAE in Whole Tissue-sensitized Guinea Pigs." Journal of Immunology (Baltimore, Md. : 1950), vol. 128, no. 2, 1982, pp. 635-8.
Driscoll BF, Kies MW, Alvord EC. Suppression of acute experimental allergic encephalomyelitis in guinea pigs by prior transfer of suboptimal numbers of EAE-effector cells: induction of chronic EAE in whole tissue-sensitized guinea pigs. J Immunol. 1982;128(2):635-8.
Driscoll, B. F., Kies, M. W., & Alvord, E. C. (1982). Suppression of acute experimental allergic encephalomyelitis in guinea pigs by prior transfer of suboptimal numbers of EAE-effector cells: induction of chronic EAE in whole tissue-sensitized guinea pigs. Journal of Immunology (Baltimore, Md. : 1950), 128(2), 635-8.
Driscoll BF, Kies MW, Alvord EC. Suppression of Acute Experimental Allergic Encephalomyelitis in Guinea Pigs By Prior Transfer of Suboptimal Numbers of EAE-effector Cells: Induction of Chronic EAE in Whole Tissue-sensitized Guinea Pigs. J Immunol. 1982;128(2):635-8. PubMed PMID: 6172501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of acute experimental allergic encephalomyelitis in guinea pigs by prior transfer of suboptimal numbers of EAE-effector cells: induction of chronic EAE in whole tissue-sensitized guinea pigs. AU - Driscoll,B F, AU - Kies,M W, AU - Alvord,E C,Jr PY - 1982/2/1/pubmed PY - 2001/3/28/medline PY - 1982/2/1/entrez SP - 635 EP - 8 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 128 IS - 2 N2 - Experimental allergic encephalomyelitis (EAE) in strain 13 guinea pigs is an acute monophasic disease induced with myelin basic protein (BP) in complete Freund's adjuvant (CFA). We report here that EAE can be effectively suppressed by transfer of a limited number of EAE-effector cells. Lymph node cells (LNC) from donors sensitized with BP/CFA are activated in vitro by incubation with BP and strain 2 peritoneal exudate cells (PEC). 5 X 10(7) of these cells are capable of inducing lethal EAE in recipients; 0.5 to 1 X 10(7) cells (a suboptimal transfer) effectively suppress EAE induction in animals subsequently sensitized with BP/CFA. Suppressed recipients develop an early mild disease from which they recover completely. In contrast, suboptimal transfer of BP-sensitized cells does not protect recipients against sensitization with whole central nervous system (CNS) tissue/CFA. About 50% of these recipients succumb to acute EAE; the survivors develop chronic EAE of varying intensity: a mild chronic form with recovery, a severe chronic form that is eventually fatal, and a chronic relapsing form that results in permanent neurologic deficit. Preliminary attempts at detecting suppressor cells in the suppressed animals were unsuccessful. Instead, PEC of all recipients of suboptimal transfers were capable of transferring EAE to naive animals. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/6172501/Suppression_of_acute_experimental_allergic_encephalomyelitis_in_guinea_pigs_by_prior_transfer_of_suboptimal_numbers_of_EAE_effector_cells:_induction_of_chronic_EAE_in_whole_tissue_sensitized_guinea_pigs_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=6172501 DB - PRIME DP - Unbound Medicine ER -