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Transfer of allergic encephalomyelitis with spleen cells from donors sensitized with myelin basic protein in incomplete Freund's adjuvant.
J Immunol. 1982 Feb; 128(2):932-4.JI

Abstract

Myelin basic protein (BP) emulsified in incomplete Freund's adjuvant (BP/IFA) is relatively nonencephalitogenic in Lewis rats. Furthermore, repeated injections of BP/IFA prevent subsequent induction of experimental allergic encephalomyelitis (EAE) by BP emulsified in complete Freund's adjuvant (BP/CFA). In spite of this, spleen cells from rats injected repeatedly with BP/IFA transfer EAE after they are cultured with BP almost as effectively as BP/CFA spleen cells. However, unlike the latter, BP/IFA spleen cells do not proliferate in response to BP in culture. Furthermore, BP/IFA spleen cells are unable to transfer EAE after culture with concanavalin A (Con A), in contrast to BP/CFA spleen cells. Both populations of spleen cells undergo a strong proliferative response to Con A in culture. For BP/IFA cells, at least, a proliferative response to BP in vitro is not a prerequisite for enhanced transfer of EAE in Lewis rats.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6172517

Citation

Namikawa, T, et al. "Transfer of Allergic Encephalomyelitis With Spleen Cells From Donors Sensitized With Myelin Basic Protein in Incomplete Freund's Adjuvant." Journal of Immunology (Baltimore, Md. : 1950), vol. 128, no. 2, 1982, pp. 932-4.
Namikawa T, Richert JR, Driscoll BF, et al. Transfer of allergic encephalomyelitis with spleen cells from donors sensitized with myelin basic protein in incomplete Freund's adjuvant. J Immunol. 1982;128(2):932-4.
Namikawa, T., Richert, J. R., Driscoll, B. F., Kies, M. W., & Alvord, E. C. (1982). Transfer of allergic encephalomyelitis with spleen cells from donors sensitized with myelin basic protein in incomplete Freund's adjuvant. Journal of Immunology (Baltimore, Md. : 1950), 128(2), 932-4.
Namikawa T, et al. Transfer of Allergic Encephalomyelitis With Spleen Cells From Donors Sensitized With Myelin Basic Protein in Incomplete Freund's Adjuvant. J Immunol. 1982;128(2):932-4. PubMed PMID: 6172517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transfer of allergic encephalomyelitis with spleen cells from donors sensitized with myelin basic protein in incomplete Freund's adjuvant. AU - Namikawa,T, AU - Richert,J R, AU - Driscoll,B F, AU - Kies,M W, AU - Alvord,E C,Jr PY - 1982/2/1/pubmed PY - 2001/3/28/medline PY - 1982/2/1/entrez SP - 932 EP - 4 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 128 IS - 2 N2 - Myelin basic protein (BP) emulsified in incomplete Freund's adjuvant (BP/IFA) is relatively nonencephalitogenic in Lewis rats. Furthermore, repeated injections of BP/IFA prevent subsequent induction of experimental allergic encephalomyelitis (EAE) by BP emulsified in complete Freund's adjuvant (BP/CFA). In spite of this, spleen cells from rats injected repeatedly with BP/IFA transfer EAE after they are cultured with BP almost as effectively as BP/CFA spleen cells. However, unlike the latter, BP/IFA spleen cells do not proliferate in response to BP in culture. Furthermore, BP/IFA spleen cells are unable to transfer EAE after culture with concanavalin A (Con A), in contrast to BP/CFA spleen cells. Both populations of spleen cells undergo a strong proliferative response to Con A in culture. For BP/IFA cells, at least, a proliferative response to BP in vitro is not a prerequisite for enhanced transfer of EAE in Lewis rats. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/6172517/Transfer_of_allergic_encephalomyelitis_with_spleen_cells_from_donors_sensitized_with_myelin_basic_protein_in_incomplete_Freund's_adjuvant_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=6172517 DB - PRIME DP - Unbound Medicine ER -