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Gluten-free diet for dermatitis herpetiformis: the long-term effect on cutaneous, immunological and jejunal manifestations.
Acta Derm Venereol. 1981; 61(5):405-11.AD

Abstract

In 32 patients with dermatitis herpetiformis (DH) we studied the effect of gluten-free (22 patients) and gluten-reduced (10 patients) diet for periods ranging between 15 and 43 months. Variables such as cutaneous manifestations, dependence on dapsone, IgA deposits in the skin, small-bowel function, and jejunal mucosal morphology were studied. 59% of the patients on gluten-free diet could stop dapsone medication and remain symptom-free, compared with 10% on gluten-reduced diet. The time needed to achieve this therapeutic response varied from 5 to 31 months. IgA decreased in the skin to a degree which roughly paralleled the morphological normalization of the jejunal mucosa. In no patient, however, did the IgA completely disappear. It is suggested that IgA is not the main factor inducing DH symptoms, but rather a secondary phenomenon. Repeated jejunal biopsies revealed normalization of the mucosal histology in 52% of the patients on gluten-free diet, compared with none in the gluten-reduced diet group.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6172928

Citation

Frödin, T, et al. "Gluten-free Diet for Dermatitis Herpetiformis: the Long-term Effect On Cutaneous, Immunological and Jejunal Manifestations." Acta Dermato-venereologica, vol. 61, no. 5, 1981, pp. 405-11.
Frödin T, Gotthard R, Hed J, et al. Gluten-free diet for dermatitis herpetiformis: the long-term effect on cutaneous, immunological and jejunal manifestations. Acta Derm Venereol. 1981;61(5):405-11.
Frödin, T., Gotthard, R., Hed, J., Molin, L., Norrby, K., & Walan, A. (1981). Gluten-free diet for dermatitis herpetiformis: the long-term effect on cutaneous, immunological and jejunal manifestations. Acta Dermato-venereologica, 61(5), 405-11.
Frödin T, et al. Gluten-free Diet for Dermatitis Herpetiformis: the Long-term Effect On Cutaneous, Immunological and Jejunal Manifestations. Acta Derm Venereol. 1981;61(5):405-11. PubMed PMID: 6172928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gluten-free diet for dermatitis herpetiformis: the long-term effect on cutaneous, immunological and jejunal manifestations. AU - Frödin,T, AU - Gotthard,R, AU - Hed,J, AU - Molin,L, AU - Norrby,K, AU - Walan,A, PY - 1981/1/1/pubmed PY - 1981/1/1/medline PY - 1981/1/1/entrez SP - 405 EP - 11 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 61 IS - 5 N2 - In 32 patients with dermatitis herpetiformis (DH) we studied the effect of gluten-free (22 patients) and gluten-reduced (10 patients) diet for periods ranging between 15 and 43 months. Variables such as cutaneous manifestations, dependence on dapsone, IgA deposits in the skin, small-bowel function, and jejunal mucosal morphology were studied. 59% of the patients on gluten-free diet could stop dapsone medication and remain symptom-free, compared with 10% on gluten-reduced diet. The time needed to achieve this therapeutic response varied from 5 to 31 months. IgA decreased in the skin to a degree which roughly paralleled the morphological normalization of the jejunal mucosa. In no patient, however, did the IgA completely disappear. It is suggested that IgA is not the main factor inducing DH symptoms, but rather a secondary phenomenon. Repeated jejunal biopsies revealed normalization of the mucosal histology in 52% of the patients on gluten-free diet, compared with none in the gluten-reduced diet group. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/6172928/Gluten_free_diet_for_dermatitis_herpetiformis:_the_long_term_effect_on_cutaneous_immunological_and_jejunal_manifestations_ L2 - https://www.diseaseinfosearch.org/result/2342 DB - PRIME DP - Unbound Medicine ER -