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Histamine release induced by neurotensin from rat peritoneal mast cells.
Eur J Pharmacol. 1981 Dec 03; 76(2-3):129-36.EJ

Abstract

Neurotensin induced the release of histamine from both purified and non-purified rat peritoneal mast cells by a non-cytotoxic mechanism. It was effective at a concentration as low as 10(-8) M. The dose-response curve for the neurotensin effect was triphasic: and initial gentle rise, a plateau (2.5 X 10(-7) -2.5 X 10(-6) M) and a second rise. Disodium cromoglycate markedly, but benzalkonium chloride only slightly, inhibited the neurotensin-induced release. The effect of neurotensin was markedly different from that of substance P, bradykinin and compound 48/80 with respect to both the dose-response curve and the sensitivity to benzalkonium chloride. These inducers of histamine release showed somewhat different effects with changes in pH and temperature. Their actions did not require extracellular Ca2+. The results indicate that neurotensin is a potent histamine releaser acting directly on mast cells. Its mode of action may be different from those of the other substances tested.

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Authors

Kurose M
No affiliation info available
Saeki K
No affiliation info available

MeSH

AnimalsAntimycin AAscitic FluidBenzalkonium CompoundsCalciumCromolyn SodiumDose-Response Relationship, DrugHistamine ReleaseHydrogen-Ion ConcentrationIn Vitro TechniquesMaleMast CellsNeurotensinRatsRats, Inbred StrainsTemperaturep-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6174350

Citation

Kurose, M, and K Saeki. "Histamine Release Induced By Neurotensin From Rat Peritoneal Mast Cells." European Journal of Pharmacology, vol. 76, no. 2-3, 1981, pp. 129-36.
Kurose M, Saeki K. Histamine release induced by neurotensin from rat peritoneal mast cells. Eur J Pharmacol. 1981;76(2-3):129-36.
Kurose, M., & Saeki, K. (1981). Histamine release induced by neurotensin from rat peritoneal mast cells. European Journal of Pharmacology, 76(2-3), 129-36.
Kurose M, Saeki K. Histamine Release Induced By Neurotensin From Rat Peritoneal Mast Cells. Eur J Pharmacol. 1981 Dec 3;76(2-3):129-36. PubMed PMID: 6174350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine release induced by neurotensin from rat peritoneal mast cells. AU - Kurose,M, AU - Saeki,K, PY - 1981/12/3/pubmed PY - 1981/12/3/medline PY - 1981/12/3/entrez SP - 129 EP - 36 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 76 IS - 2-3 N2 - Neurotensin induced the release of histamine from both purified and non-purified rat peritoneal mast cells by a non-cytotoxic mechanism. It was effective at a concentration as low as 10(-8) M. The dose-response curve for the neurotensin effect was triphasic: and initial gentle rise, a plateau (2.5 X 10(-7) -2.5 X 10(-6) M) and a second rise. Disodium cromoglycate markedly, but benzalkonium chloride only slightly, inhibited the neurotensin-induced release. The effect of neurotensin was markedly different from that of substance P, bradykinin and compound 48/80 with respect to both the dose-response curve and the sensitivity to benzalkonium chloride. These inducers of histamine release showed somewhat different effects with changes in pH and temperature. Their actions did not require extracellular Ca2+. The results indicate that neurotensin is a potent histamine releaser acting directly on mast cells. Its mode of action may be different from those of the other substances tested. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/6174350/Histamine_release_induced_by_neurotensin_from_rat_peritoneal_mast_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0014-2999(81)90494-5 DB - PRIME DP - Unbound Medicine ER -