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Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain?
Br J Pharmacol. 1982 Mar; 75(3):525-30.BJ

Abstract

1 The effects of (+)-fenfluramine, (+)-norfenfluramine and reserpine on the concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in brainstem and telencephalon were studied in rats treated with methergoline, a 5-HT antagonist. 2 Methergoline significantly reduced the effect of (+)-norfenfluramine (5 mg/kg) on 5-HT levels in telencephalon and brainstem but did not modify the effect of (+)-norfenfluramine (2.5 mg/kg). 3 Neither the effect of (+)-fenfluramine on 5-HT levels nor the decrease of 5-HT metabolism caused by (+)-fenfluramine and (+)-norfenfluramine was significantly modified by methergoline treatment. 4 Methergoline potentiated the effects of reserpine on brain indoles. The effects was particularly evident on 5-HIAA levels in the brainstem, although significant effects were found on 5-HT in the brainstem and 5-HIAA in the telencephalon depending on the dose reserpine used. 5 The results show that postsynaptic receptor activation may partially contribute to the depletion of brain 5-HT caused by (+)-norfenfluramine in the rat. This mechanism does not seem to play a significant role in the effect of (+)-fenfluramine.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6175368

Citation

Invernizzi, R, et al. "Is Receptor Activation Involved in the Mechanism By Which (+)-fenfluramine and (+)-norfenfluramine Deplete 5-hydroxytryptamine in the Rat Brain?" British Journal of Pharmacology, vol. 75, no. 3, 1982, pp. 525-30.
Invernizzi R, Kmieciak-Kolada K, Samanin R. Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain? Br J Pharmacol. 1982;75(3):525-30.
Invernizzi, R., Kmieciak-Kolada, K., & Samanin, R. (1982). Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain? British Journal of Pharmacology, 75(3), 525-30.
Invernizzi R, Kmieciak-Kolada K, Samanin R. Is Receptor Activation Involved in the Mechanism By Which (+)-fenfluramine and (+)-norfenfluramine Deplete 5-hydroxytryptamine in the Rat Brain. Br J Pharmacol. 1982;75(3):525-30. PubMed PMID: 6175368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain? AU - Invernizzi,R, AU - Kmieciak-Kolada,K, AU - Samanin,R, PY - 1982/3/1/pubmed PY - 1982/3/1/medline PY - 1982/3/1/entrez SP - 525 EP - 30 JF - British journal of pharmacology JO - Br J Pharmacol VL - 75 IS - 3 N2 - 1 The effects of (+)-fenfluramine, (+)-norfenfluramine and reserpine on the concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in brainstem and telencephalon were studied in rats treated with methergoline, a 5-HT antagonist. 2 Methergoline significantly reduced the effect of (+)-norfenfluramine (5 mg/kg) on 5-HT levels in telencephalon and brainstem but did not modify the effect of (+)-norfenfluramine (2.5 mg/kg). 3 Neither the effect of (+)-fenfluramine on 5-HT levels nor the decrease of 5-HT metabolism caused by (+)-fenfluramine and (+)-norfenfluramine was significantly modified by methergoline treatment. 4 Methergoline potentiated the effects of reserpine on brain indoles. The effects was particularly evident on 5-HIAA levels in the brainstem, although significant effects were found on 5-HT in the brainstem and 5-HIAA in the telencephalon depending on the dose reserpine used. 5 The results show that postsynaptic receptor activation may partially contribute to the depletion of brain 5-HT caused by (+)-norfenfluramine in the rat. This mechanism does not seem to play a significant role in the effect of (+)-fenfluramine. SN - 0007-1188 UR - https://www.unboundmedicine.com/medline/citation/6175368/Is_receptor_activation_involved_in_the_mechanism_by_which__+__fenfluramine_and__+__norfenfluramine_deplete_5_hydroxytryptamine_in_the_rat_brain L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-1188&date=1982&volume=75&issue=3&spage=525 DB - PRIME DP - Unbound Medicine ER -