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Histamine release from rat peritoneal mast cells exposed to ultraviolet light.
Acta Derm Venereol. 1982; 62(3):215-20.AD

Abstract

After irradiation with ultraviolet light, rat peritoneal mast cells incubated with the histamine liberator compound 48/80 were found to have reduced capacity to release histamine. The action spectrum for histamine release inhibition seemed to be in the wavelength region of UVB. UV-light per se did not induce histamine liberation other than for dosages greater than or equal to 1.45 J/cm2. No such release was observed with the doses of UVA studied (3.4-20.5 J/cm2). The metabolic inhibitor 2.4-dinitrophenol (DNP), which almost completely inhibited compound 48/80-elicited histamine release, did not influence the UV-induced histamine release, indicating that the latter was not a secretory process but due to cytotoxic leakage of histamine from the cells. These results suggest that inhibition of histamine-releasing capacity or reduction of skin histamine due to photolysis of mast cells may explain the beneficial effect of UV in pruritic disorders where histamine release from mast cells is involved.

Authors

Fjellner B
No affiliation info available
Hägermark O
No affiliation info available

MeSH

AnimalsAscitic FluidDose-Response Relationship, RadiationHistamine ReleaseMaleMast CellsRatsRats, Inbred StrainsUltraviolet Raysp-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6179361

Citation

Fjellner, B, and O Hägermark. "Histamine Release From Rat Peritoneal Mast Cells Exposed to Ultraviolet Light." Acta Dermato-venereologica, vol. 62, no. 3, 1982, pp. 215-20.
Fjellner B, Hägermark O. Histamine release from rat peritoneal mast cells exposed to ultraviolet light. Acta Derm Venereol. 1982;62(3):215-20.
Fjellner, B., & Hägermark, O. (1982). Histamine release from rat peritoneal mast cells exposed to ultraviolet light. Acta Dermato-venereologica, 62(3), 215-20.
Fjellner B, Hägermark O. Histamine Release From Rat Peritoneal Mast Cells Exposed to Ultraviolet Light. Acta Derm Venereol. 1982;62(3):215-20. PubMed PMID: 6179361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine release from rat peritoneal mast cells exposed to ultraviolet light. AU - Fjellner,B, AU - Hägermark,O, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 215 EP - 20 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 62 IS - 3 N2 - After irradiation with ultraviolet light, rat peritoneal mast cells incubated with the histamine liberator compound 48/80 were found to have reduced capacity to release histamine. The action spectrum for histamine release inhibition seemed to be in the wavelength region of UVB. UV-light per se did not induce histamine liberation other than for dosages greater than or equal to 1.45 J/cm2. No such release was observed with the doses of UVA studied (3.4-20.5 J/cm2). The metabolic inhibitor 2.4-dinitrophenol (DNP), which almost completely inhibited compound 48/80-elicited histamine release, did not influence the UV-induced histamine release, indicating that the latter was not a secretory process but due to cytotoxic leakage of histamine from the cells. These results suggest that inhibition of histamine-releasing capacity or reduction of skin histamine due to photolysis of mast cells may explain the beneficial effect of UV in pruritic disorders where histamine release from mast cells is involved. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/6179361/Histamine_release_from_rat_peritoneal_mast_cells_exposed_to_ultraviolet_light_ DB - PRIME DP - Unbound Medicine ER -