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Concurrent antiglomerular basement membrane antibody and immune complex mediated glomerulonephritis.
Am J Clin Pathol. 1982 Sep; 78(3):381-6.AJ

Abstract

A teenage male, with Goodpasture's syndrome and serum antiglomerular basement membrane (anti-GBM) antibodies, had a focal proliferative glomerulonephritis with crescents. Immunofluorescence microscopy of his glomeruli using anti-IgG antibodies demonstrated both intense linear GBM staining, and granular subepithelial staining. Electron microscopy revealed numerous subepithelial electron-dense deposits. Identical IgG subclass restriction (dominance of IgG1 and IgG4) of both types of glomerular deposits in this patient supports, but does not prove, a postulate that the linear staining was due to anti-GBM antibodies bound to intact GBM, and that the granular staining was due to anti-GBM antibodies complexed with freed GBM antigens.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6180630

Citation

Jennette, J C., et al. "Concurrent Antiglomerular Basement Membrane Antibody and Immune Complex Mediated Glomerulonephritis." American Journal of Clinical Pathology, vol. 78, no. 3, 1982, pp. 381-6.
Jennette JC, Lamanna RW, Burnette JP, et al. Concurrent antiglomerular basement membrane antibody and immune complex mediated glomerulonephritis. Am J Clin Pathol. 1982;78(3):381-6.
Jennette, J. C., Lamanna, R. W., Burnette, J. P., Wilkman, A. S., & Iskander, S. S. (1982). Concurrent antiglomerular basement membrane antibody and immune complex mediated glomerulonephritis. American Journal of Clinical Pathology, 78(3), 381-6.
Jennette JC, et al. Concurrent Antiglomerular Basement Membrane Antibody and Immune Complex Mediated Glomerulonephritis. Am J Clin Pathol. 1982;78(3):381-6. PubMed PMID: 6180630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concurrent antiglomerular basement membrane antibody and immune complex mediated glomerulonephritis. AU - Jennette,J C, AU - Lamanna,R W, AU - Burnette,J P, AU - Wilkman,A S, AU - Iskander,S S, PY - 1982/9/1/pubmed PY - 1982/9/1/medline PY - 1982/9/1/entrez SP - 381 EP - 6 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 78 IS - 3 N2 - A teenage male, with Goodpasture's syndrome and serum antiglomerular basement membrane (anti-GBM) antibodies, had a focal proliferative glomerulonephritis with crescents. Immunofluorescence microscopy of his glomeruli using anti-IgG antibodies demonstrated both intense linear GBM staining, and granular subepithelial staining. Electron microscopy revealed numerous subepithelial electron-dense deposits. Identical IgG subclass restriction (dominance of IgG1 and IgG4) of both types of glomerular deposits in this patient supports, but does not prove, a postulate that the linear staining was due to anti-GBM antibodies bound to intact GBM, and that the granular staining was due to anti-GBM antibodies complexed with freed GBM antigens. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/6180630/Concurrent_antiglomerular_basement_membrane_antibody_and_immune_complex_mediated_glomerulonephritis_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1093/ajcp/78.3.381 DB - PRIME DP - Unbound Medicine ER -