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H2 antihistamines augment antigen-induced histamine release from human basophils in vitro.
J Immunol. 1982 Nov; 129(5):2113-5.JI

Abstract

H2 antihistamines, including cimetidine, burimamide, metiamide, and tiotidine, consistently augmented antigen-induced histamine release from human basophils in vitro when control histamine release was less than 20% of total. This effect was specific to the H2-receptor blocking activity of these drugs: equivalent degrees of receptor blockade by four different H2 antihistamines resulted in equipotent enhancement; H1-receptor antagonists did not alter histamine release; and aminoguanidine and amodiaquine, agents that inhibit histamine metabolism but do not block H2 receptors, did not enhance histamine release. Cimetidine did not enhance release when present a) when basophils were "activated" but did not release histamine ("first stage"), or b) when basophils were no longer susceptible to histamine inhibition ("second stage"). Thus, H2 antagonists enhanced histamine release by blocking the capacity of released histamine to act on H2 receptors to inhibit release. Because it is likely that only small percentages of histamine are released in vivo, it is possible that H2 antihistamines amplify the inflammatory process by blocking the inhibitory effects of the released histamine.

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Publisher Full Text

Authors

Tung R
No affiliation info available
Kagey-Sobotka A
No affiliation info available
Plaut M
No affiliation info available
Lichtenstein LM
No affiliation info available

MeSH

AmodiaquineAntigensBasophilsChlorpheniramineCimetidineDimapritDiphenhydramineHistamine H2 AntagonistsHistamine N-MethyltransferaseHistamine ReleaseHumansStimulation, ChemicalThiourea

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6181161

Citation

Tung, R, et al. "H2 Antihistamines Augment Antigen-induced Histamine Release From Human Basophils in Vitro." Journal of Immunology (Baltimore, Md. : 1950), vol. 129, no. 5, 1982, pp. 2113-5.
Tung R, Kagey-Sobotka A, Plaut M, et al. H2 antihistamines augment antigen-induced histamine release from human basophils in vitro. J Immunol. 1982;129(5):2113-5.
Tung, R., Kagey-Sobotka, A., Plaut, M., & Lichtenstein, L. M. (1982). H2 antihistamines augment antigen-induced histamine release from human basophils in vitro. Journal of Immunology (Baltimore, Md. : 1950), 129(5), 2113-5.
Tung R, et al. H2 Antihistamines Augment Antigen-induced Histamine Release From Human Basophils in Vitro. J Immunol. 1982;129(5):2113-5. PubMed PMID: 6181161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - H2 antihistamines augment antigen-induced histamine release from human basophils in vitro. AU - Tung,R, AU - Kagey-Sobotka,A, AU - Plaut,M, AU - Lichtenstein,L M, PY - 1982/11/1/pubmed PY - 1982/11/1/medline PY - 1982/11/1/entrez SP - 2113 EP - 5 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 129 IS - 5 N2 - H2 antihistamines, including cimetidine, burimamide, metiamide, and tiotidine, consistently augmented antigen-induced histamine release from human basophils in vitro when control histamine release was less than 20% of total. This effect was specific to the H2-receptor blocking activity of these drugs: equivalent degrees of receptor blockade by four different H2 antihistamines resulted in equipotent enhancement; H1-receptor antagonists did not alter histamine release; and aminoguanidine and amodiaquine, agents that inhibit histamine metabolism but do not block H2 receptors, did not enhance histamine release. Cimetidine did not enhance release when present a) when basophils were "activated" but did not release histamine ("first stage"), or b) when basophils were no longer susceptible to histamine inhibition ("second stage"). Thus, H2 antagonists enhanced histamine release by blocking the capacity of released histamine to act on H2 receptors to inhibit release. Because it is likely that only small percentages of histamine are released in vivo, it is possible that H2 antihistamines amplify the inflammatory process by blocking the inhibitory effects of the released histamine. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/6181161/H2_antihistamines_augment_antigen_induced_histamine_release_from_human_basophils_in_vitro_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=6181161 DB - PRIME DP - Unbound Medicine ER -